Volume 431, Issue 1 p. 505-513
Research Article
Free to Read

Permeability of the human placenta in vivo to four non-metabolized hydrophilic molecules.

M D Bain

M D Bain

Clinical Research Centre, Harrow.

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D K Copas

D K Copas

Clinical Research Centre, Harrow.

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A Taylor

A Taylor

Clinical Research Centre, Harrow.

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M J Landon

M J Landon

Clinical Research Centre, Harrow.

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T E Stacey

T E Stacey

Clinical Research Centre, Harrow.

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First published: 01 December 1990
Citations: 33

Abstract

1. Permeability of the human placenta to four permeants of different molecular size was measured at Caesarean section in seven normal full-term pregnancies. 2. Placental clearance for mannitol was 8.7 +/- 1.1 ml min-1 (mean +/- S.E.M.), lactulose 6.3 +/- 0.8, chromium ethylenediaminetetraacetic acid (CrEDTA) 3.7 +/- 0.5, and inulin 0.98 +/- 0.1. 3. The permeability data were analysed in terms of restricted diffusion through ‘notional’ water-filled pores and found to be incompatible with a single population of uniform pores.