White Paper
Translational neurocardiology: preclinical models and cardioneural integrative aspects
J. L. Ardell,
M. C. Andresen,
J. A. Armour,
G. E. Billman,
P.-S. Chen,
R. D. Foreman,
N. Herring,
D. S. O'Leary,
H. N. Sabbah,
H. D. Schultz,
K. Sunagawa,
I. H. Zucker,
Corresponding Author
J. L. Ardell
University of California – Los Angeles (UCLA) Cardiac Arrhythmia Center, David Geffen School of Medicine, Los Angeles, CA, USA
UCLA Neurocardiology Research Center of Excellence, David Geffen School of Medicine, Los Angeles, CA, USA
Corresponding author J. L. Ardell: Department of Medicine (Cardiology), UCLA Cardiac Arrhythmia Center and UCLA Neurocardiology Research Center of Excellence, 100 Medical Plaza, Suite 660, Los Angeles, CA 90095, USA. Email: [email protected]Search for more papers by this authorM. C. Andresen
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR, USA
Search for more papers by this authorJ. A. Armour
University of California – Los Angeles (UCLA) Cardiac Arrhythmia Center, David Geffen School of Medicine, Los Angeles, CA, USA
UCLA Neurocardiology Research Center of Excellence, David Geffen School of Medicine, Los Angeles, CA, USA
Search for more papers by this authorG. E. Billman
Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA
Search for more papers by this authorP.-S. Chen
The Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Search for more papers by this authorR. D. Foreman
Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Search for more papers by this authorN. Herring
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Search for more papers by this authorD. S. O'Leary
Department of Physiology, Wayne State University, Detroit, MI, USA
Search for more papers by this authorH. N. Sabbah
Department of Medicine, Henry Ford Hospital, Detroit, MI, USA
Search for more papers by this authorH. D. Schultz
Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA
Search for more papers by this authorK. Sunagawa
Department of Cardiovascular Medicine, Kyushu University, Fukuoka, Japan
Search for more papers by this authorI. H. Zucker
Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA
Search for more papers by this authorJ. L. Ardell,
M. C. Andresen,
J. A. Armour,
G. E. Billman,
P.-S. Chen,
R. D. Foreman,
N. Herring,
D. S. O'Leary,
H. N. Sabbah,
H. D. Schultz,
K. Sunagawa,
I. H. Zucker,
Corresponding Author
J. L. Ardell
University of California – Los Angeles (UCLA) Cardiac Arrhythmia Center, David Geffen School of Medicine, Los Angeles, CA, USA
UCLA Neurocardiology Research Center of Excellence, David Geffen School of Medicine, Los Angeles, CA, USA
Corresponding author J. L. Ardell: Department of Medicine (Cardiology), UCLA Cardiac Arrhythmia Center and UCLA Neurocardiology Research Center of Excellence, 100 Medical Plaza, Suite 660, Los Angeles, CA 90095, USA. Email: [email protected]Search for more papers by this authorM. C. Andresen
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR, USA
Search for more papers by this authorJ. A. Armour
University of California – Los Angeles (UCLA) Cardiac Arrhythmia Center, David Geffen School of Medicine, Los Angeles, CA, USA
UCLA Neurocardiology Research Center of Excellence, David Geffen School of Medicine, Los Angeles, CA, USA
Search for more papers by this authorG. E. Billman
Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA
Search for more papers by this authorP.-S. Chen
The Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Search for more papers by this authorR. D. Foreman
Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Search for more papers by this authorN. Herring
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Search for more papers by this authorD. S. O'Leary
Department of Physiology, Wayne State University, Detroit, MI, USA
Search for more papers by this authorH. N. Sabbah
Department of Medicine, Henry Ford Hospital, Detroit, MI, USA
Search for more papers by this authorH. D. Schultz
Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA
Search for more papers by this authorK. Sunagawa
Department of Cardiovascular Medicine, Kyushu University, Fukuoka, Japan
Search for more papers by this authorI. H. Zucker
Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA
Search for more papers by this authorAbstract
Neuronal elements distributed throughout the cardiac nervous system, from the level of the insular cortex to the intrinsic cardiac nervous system, are in constant communication with one another to ensure that cardiac output matches the dynamic process of regional blood flow demand. Neural elements in their various ‘levels’ become differentially recruited in the transduction of sensory inputs arising from the heart, major vessels, other visceral organs and somatic structures to optimize neuronal coordination of regional cardiac function. This White Paper will review the relevant aspects of the structural and functional organization for autonomic control of the heart in normal conditions, how these systems remodel/adapt during cardiac disease, and finally how such knowledge can be leveraged in the evolving realm of autonomic regulation therapy for cardiac therapeutics.
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