Special Issues

The Journal of Physiology publishes reviews on current topics, from researchers in emerging areas, in Special Issues. See our current ‘Call for Papers’.


JP 15 June 2017 - Volume 595 - Number 10
Cardiac regulatory mechanisms

JP 15 May 2017 - Volume 595 - Number 10
Advances in calcium signalling

JP 1 May 2017 - Volume 595 - Number 9
Biomedical Basis of Elite Performance

JP 1 April 2017 - Volume 595 - Number 7
K+ channels and cardiac electrophysiology

JP 15 February 2017 - Volume 595 - Number 2
Influence of the microbiota on host physiology - moving beyond the gut



1 December 2016 - Volume 594 - Number 23
The Cardiac Physiome Project

JP 15 September 2016 - Volume 594 - Number 18
Exercise and Oxidative Stress


1 September 2016 - Volume 594 - Number 17
GI stem cells – new insights into roles in physiology and pathophysiology


15 August 2016 - Volume 594 - Number 16
 The neuroscience of ageing and degenaration


15 July 2016 - Volume 594 - Number 14
Cardiac Autonomic Controlin Health and Disease


1 May 2016 - Volume 594 - Number 9
Cardiac Arrhythmias: Challenges for Diagnosis and Treatment


15 April 2016 - Volume 594 - Number 8
Cardiovascular and skeletal muscle ageing: consequences for longevity


1 March 2016 - Volume 594 - Number 5
Hypoxia, fetal and neonatal physiology: 100 years on from Sir Joseph Barcroft



15 September 2015 - Volume 593 - Number 18
Twenty‐five years of CLC transport proteins


1 March 2015 - Volume 593 - Number 6
Sodium and calcium regulation in cardiac myocytes: from molecules to heart failure and arrhythmia



15 September 2014 - Volume 592 - Number 18
The kidney – an organ of critical importance in physiology

Reviews on the subject of the kidney, with an overview by Louise Robson.


15 July 2014 - Volume 592 - Number 14
Neurohormonal signalling in the gastrointestinal tract – new frontiers


1 June 2014 - Volume 592 - Number 11
The integration of evolutionary biology with physiological science



1 September 2013 - Volume 591- Number 17
Arrhythmia: 100 years on from George Ralph Mines


1 January 2013 - Volume 591- Number 1
Neuroscience from the Florey Institute



15 September 2012 - Volume 590 - Number 18
The cardiac physiome – computational physiology


1 June 2012 - Volume 590 - Number 11
Voltage-gated ion channels: celebrating 60 years
Reviews - William A. Catterall, Lily Yeh Jan, Stephen G. Waxman, Denis Noble


1 February 2012 - Volume 590 - Number 3
Epithelial biology in the gastrointestinal system
Reviews - Juanita Merchant, Gail Hecht, Helen Raybould and Bernd Schnabl



1 January 2011 - Volume 589 - Number 1
Information processing in the primate visual system
Reviews - Paul Martin, Samuel Solomon, Farran Briggs, Martin Usrey, Barry Lee and James Bisley



1 March 2011 - Volume 589 - Number 5
Systems biology in a physiological world
Reviews - Michael J. Joyner, Denis Noble, Paul Greenhaff, Dirk J. Duncker, Timothy W. Secomb and Robert L. Hester



15 March 2011 - Volume 589 - Number 6
Synthesis, function and possible new avenues for erythropoietin
Reviews - Carsten Lundby, Wolfgang Jelkmann, Johannes Vogel, Max Gassmann and Niels Vidiendal Olsen



1 January 2010 - Volume 588 - Number 1
Structure, function and neurophysiology of inhibitory and excitatory amino acid receptors
Reviews - Derek Bowie, Kris Krnjevic, Lucia Sivilotti, David Weiss, James Howe, Pierre Paoletti, rosa Cossart, Stephanie Oilet, Anne McKinney, Jean-Marc Fritschy and Christophe Mulle


1 June 2010 - Volume 588 - Number 11
Neurological channelopathies
Reviews - Dimitri Kullmann, Stephen G. Waxman, Michael Hanna, William Catterall, Miriam Meisler, Sulayman Dib-Hajj, John Wood, Daniela Pietrobon, Jeff Noebels, Robert MacDonald, Hugh Bostock and Sam Berkovic


1 December 2010 - Volume 588 - Number 23
Voltage and ion sensing channels: three views of the same tale
Reviews - Yasushi Okamura, Jianmin Cui, Nicolas Demaurex, Antoun El Chemaly, Polina Lishko and Yuriy Kirichok



15 June 2009 - Volume 587 - Number 12
Receptive fields of single neurones in the cat's striate cortex
50th anniversary of David Hubel and Torsten Wiesel
Reviews - Erik Kandel, Nigel Daw, John Nicholls, Robert Wurtz, Semir Zeki and
David Hubel



1 January 2008 - Volume 586 - Number 1
Olympics special: Exercise physiology and human performance
Reviews - Michael Joyner, Bengt Saltin, Roger Enoka, Benjamin Levine, Jens Bo Nielsen,
Leonardo Cohen and Michael Kjaer



1 January 2007 - Volume 578 - Number 1
From genotype to phenotype and back
Reviews - Michael Kotlikoff, Roger Hardie, Bjarte Furnes, John Schimenti, Kenton Sanders, Sean Ward, Guy Salama and Barry London

Funder Compliance

Editor's Choice

15 January  - Volume 596 Issue 2

Using proprioception to get a better grasp on embodiment

Paul D. Marasco

Sustained cardiac programming by short-term juvenile exercise training in male rats

Y. Asif, M. E. Wlodek, M. J. Black, A. P. Russell, P. F. Soeding, G. D. Wadley

Regulation of TMEM16A/ANO1 and TMEM16F/ANO6 ion currents and phospholipid scrambling by Ca2+ and plasma membrane lipid

Rainer Schreiber, Jiraporn Ousingsawat, Podchanart Wanitchakool, Lalida Sirianant, Roberta Benedetto, Karina Reiss, Karl Kunzelmann

Time, touch and temperature affect perceived finger position and ownership in the grasp illusion

Martin E. Héroux, Nicolas Bayle, Annie A. Butler, Simon C. Gandevia

Short-term high-fat diet primes excitatory synapses for long-term depression in orexin neurons

Victoria Linehan, Lisa Z. Fang, Michiru Hirasawa

See all »

Experimental Biology joint virtual issue 2017

Joint Virtual Issue - Experimental Biology 2017

Reflecting the increasingly interdisciplinary nature of life science research, this collection brings together articles published in the journals of the Biochemical Society, the British Pharmacological Society, ASPET and The Physiological Society. Key topics highlighted include neurobiology, gastrointestinal biology, obesity, nutrition, and epigenetics.

All articles are free to read until 31 May. We hope you enjoy our collection!


The repair Schwann cell and its function in regenerating nerves
The Journal of Physiology | K. R. Jessen & R. Mirsky | 10.1113/JP270874

What do we really know about newborn infant pain?
Experimental Physiology | Maria Fitzgerald | 10.1113/EP085134

Retrograde apoptotic signaling by the p75 neurotrophin receptor
Neuronal Signaling | Amrita Pathak & Bruce D. Carter  | 10.1042/NS20160007

Extracellular matrix inflammation in vascular cognitive impairment and dementia
Clinical Science | Gary A. Rosenberg | 10.1042/CS20160604

Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction
Biochemical Journal | Paul Bishop et al | 10.1042/BCJ20160082

Relaxin’ the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders
British Journal of Clinical Pharmacology | Jigna Rajesh Kumar et al | 10.1111/bph.13564

Pharmacological comparison of a nonhuman primate and a rat model of oxaliplatin-induced neuropathic cold hypersensitivity
Pharmacology Research & Perspectives |Yuka Shidahara et al | 10.1002/prp2.216

Gastrointestinal biology

Endogenous and exogenous control of gastrointestinal epithelial function: building on the legacy of Bayliss and Starling
The Journal of Physiology | Kim E. Barrett | 10.1113/JP272227

Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in Sprague–Dawley rats
Experimental Physiology | Maria M. Buckleyet al | 10.1113/EP085917

Gastrointestinal transport of calcium and glucose in lactating ewes
Physiological Reports | Stefanie Klinger et al | 10.14814/phy2.12817

Foxa2 and Hif1ab regulate maturation of intestinal goblet cells by modulating agr2 expression in zebrafish embryos
Biochemical Journal | Yun-Ren Lai et al| 10.1042/BCJ20160392

Age-associated modifications of intestinal permeability and innate immunity in human small intestine
Clinical Science | Angela L. Mani et al|10.1042/CS20150046

Prescription behavior for gastroprotective drugs in new users as a result of communications regarding clopidogrel – proton pump inhibitor interaction
Pharmacology Research & Perspectives | Willemien J. Kruik-Kollöffel et al| 10.1002/prp2.242

Octreotide s.c. depot provides sustained octreotide bioavailability and similar IGF-1 suppression to octreotide LAR in healthy volunteers
British Journal of Clinical Pharmacology | F Tiberg et al| 10.1111/bcp.12698

Hydrogen sulphide protects against NSAID-enteropathy through modulation of bile and the microbiota
British Journal of Pharmocology |RW Blackler et al| 10.1111/bph.12961


Resveratrol supplementation of high-fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring
The Journal of Physiology | Tiande Zou et al | 10.1113/JP273478

Oxidative stress and immunosenescence in spleen of obese mice can be reversed by 2-hydroxyoleic acid
Experimental Physiology | Alina Gheorghe et al | 10.1113/EP086157

Similar degrees of obesity induced by diet or aging cause strikingly different immunologic and metabolic outcomes
Physiological Reports | Kanthi B. Krishna at al | 0.14814/phy2.12708

Energy balalance, body composition, sedentariness and appetite regulation: pathways to obesity
Clinical Sciences | Mark Hopkins et al | 10.1042/CS20160006

New insight on obesity and adipose-derived stem cells using comprehensive metabolomics
Biochemical Journal |Annalaura Mastrangelo at al | 10.1042/BCJ20160241

A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes
Pharmacology Research & Perspectives | Yanyun Chen et al | 10.1002/prp2.278

The effectiveness of pharmaceutical interventions for obesity: weight loss with orlistat and sibutramine in a United Kingdom population-based cohort
British Journal of Clinical Pharmocology | IJ Douglas et al | 10.1111/bcp.12578

Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning
British Journal of Pharmocology | TM Henagan at al | 10.1111/bph.13058


Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers
The Journal of Physiology | Louise M. Burke et al | 10.1113/JP273230

Long term dietary quercetin enrichment as a cardioprotective countermeasure in mdx mice
Experimental Physiology | Christopher Ballmannl et al | 10.1113/EP086091

Undernutrition in pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring
Bioscience Reports |Brittany Beauchamp et al | 10.1042/BSR20150007

Blood triacylglycerols: a lipidomic window on diet and disease
Biochemical Society Transactions | Francis Saunders et al | 10.1042/BST20150235

The potential health effects of dietary phytoestrogens
British Journal of Pharmocology | Ivonne M C M Rietjens at al | 10.1111/bph.13622

Mediterranean diet, dietary polyphenols and low grade inflammation: results from the MOLI-SANI study
British Journal of Clinical Pharmocology |Marialaura Bonaccio at al | 10.1111/bcp.12924


Late gestational intermittent hypoxia induces metabolic and epigenetic changes in male adult offspring mice
The Journal of Physiology |Abdelnaby Khalyfa et al | 10.1113/JP273570

Multigenerational effects of fetal-neonatal iron deficiency on hippocampal BDNF signaling
Physiological Reports | Mariah B. Blegen et al | 10.1002/phy2.96

Epigenetic inheritance of proteostasis and ageing
Essays in Biochemistry | Cheryl Li & Olivia Casanueva | 10.1042/EBC20160025

Epigenetic regulation of skeletal muscle metabolism
Clinical Science | Kirsten F Howlet &, Sean L McGee | 10.1042/CS20160115

A saga of cancer epigenetics: linking epigenetics to alternative splicing
Biochemical Journal| Sathiya Pandi Narayanan et al | 10.1042/BCJ20160147

Downregulation of the Ca2+-activated K+ channel KCa3.1 by histone deacetylase inhibition in human breast cancer cells
Pharmacology Research & Perspectivesl | Susumu Ohya et al | 10.1002/prp2.228

Therapeutic perspectives of epigenetically active nutrients
British Journal of Pharmocology | M Remely et al | 10.1111/bph.12854