Cross Talk Debates



Introducing CrossTalk in The Journal of Physiology


List of CrossTalk debates


33. Proton permeation through HV1 requires transient protonation of a conserved aspartate in the S1 transmembrane helix

32. Skeletal muscle oxidative capacity is altered in patients with cystic fibrosis

31. Metabolic syndrome causes sleep apnoea / Sleep apnoea causes metabolic syndrome

30. The middle cerebral artery diameter does/does not change during alterations in arterial blood gases and blood pressure

29. Intramyocellular ceramide accumulation does/does not modulate insulin resistance

28. Interstitial cells are/are not involved and physiologically important in neuromuscular transmission in the gut

27. Heat acclimatization does/does not improve performance in a cool condition 

26. High intensity interval training does/does not have a role in risk reduction or treatment of disease 

25.Physiological CO2 exchange can depend on membrane channels

24. Diffusion limitation of O2 from microvessels into muscle does contribute to the limitation of V̇O2 max

23. 5-HT is necessary for peristalsis

22. Fear of falling does influence vestibular-evoked balance responses

21.Bradycardia in the trained athlete is attributable to high vagal tone

20. The dominant mechanism causing disuse muscle atrophy is decreased protein synthesis/proteolysis

19. De novo capillary recruitment in healthy muscle is/is not necessary to explain physiological outcomes

18. Which technique for controlling resistant hypertension?

17. Rotors have/have not been demonstrated to drive human atrial fibrillation

16. Elevated loop gain is/is not a consequence of obstructive sleep apnoea

15. Weighing the evidence for Class A GPCR dimers, the evidence favours dimers/the jury is still out

14. The preBötzinger complex is/is not essential for the respiratory depression following systemic administration of opioid analgesics

13. The late sodium current is/is not an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction)

12. Cell volume changes are/are not an essential step in the cell death machinery

11. Guyton's venous return curves should/should not be taught

10. The diaphragm muscle does/does not atrophy as a result of inactivity

9. Prolonged intense exercise training does/does not lead to myocardial damage (15 October 2013)

8. Peripheral and central chemoreflexes have additive/ hypoadditive/ hyperadditive effects on ventilation in humans (15 September 2013)

7. There is/there is not added benefit to providing permissive hypercapnia in the treatment of ARDS (1 June 2013)

6. The human upper airway does/does not behave like a Starling resistor during sleep (1 May 2013)

5. TARPs modulate AMPA receptor gating transitions/AMPA receptor conformations before the gating transitions (1 April 2013)

4. Forward and backward pressure waves in the arterial system do/do not represent reality (1 March 2013)

3. The intermittent hypoxia attending severe obstructive sleep apnoea does/does not lead to alterations in brain structure and function (15 Janaury 2013)

2. Training the respiratory muscles does/does not improve exercise tolerance (1 August 2012)

1. Most of the cardiovascular consequences of OSA are due/not dueto increased sympathetic activity (15 June 2012)


CrossTalk debate 33 published 11 October 2017

Proton permeation through HV1 requires transient protonation of a conserved aspartate in the S1 transmembrane helix

CrossTalk proposal: Proton permeation through HV1 requires transient protonation of a conserved aspartate in the S1 transmembrane helix
Thomas E. DeCoursey
First Published: 11 October 2017 DOI: 10.1113/JP274495

CrossTalk opposing view: proton transfer in Hv1 utilizes a water wire, and does not require transient protonation of a conserved aspartate in the S1 transmembrane helix
Ashley L. Bennett, Ian Scott Ramsey
First Published: 11 October 2017 DOI: 10.1113/JP274553

Rebuttal from Thomas E. DeCoursey
Thomas E. DeCoursey
First Published: 11 October 2017 DOI: 10.1113/JP274982

Rebuttal from Ashley L. Bennett and Ian Scott Ramsey
Ashley L. Bennett, Ian Scott Ramsey
First Published: 11 October 2017 DOI: 10.1113/JP274984


CrossTalk debate 32 published 28 February 2017

Skeletal muscle oxidative capacity is altered in patients with cystic fibrosis

CrossTalk proposal: Skeletal muscle oxidative capacity is altered in patients with cystic fibrosis
Paula Rodriguez‐Miguelez, Melissa L. Erickson, Kevin K. McCully, Ryan A. Harris
First Published:28 February 2017Vol: 595, Pages: 1423–1425DOI: 10.1113/JP272486

CrossTalk opposing view: Skeletal muscle oxidative capacity is not altered in cystic fibrosis patients
H. J. (Erik) Hulzebos, Jeroen A. L. Jeneson, Cornelis K. van der Ent, Tim Takken
First Published:28 February 2017Vol: 595, Pages: 1427–1428DOI: 10.1113/JP272505

Rebuttal from Paula Rodriguez‐Miguelez, Melissa L. Erickson, Kevin K. McCully and Ryan A. Harris
Paula Rodriguez‐Miguelez, Melissa L. Erickson, Kevin K. McCully, Ryan A. Harris
First Published:28 February 2017Vol: 595, Pages: 1429DOI: 10.1113/JP273738

Rebuttal from Erik H. J. Hulzebos, Jeroen A. L. Jeneson, Cornelis K. van der Ent, Maarten S. Werkman and Tim Takken
H. J. (Erik) Hulzebos, Jeroen A. L. Jeneson, Cornelis K. van der Ent, Maarten S. Werkman, Tim Takken
First Published:28 February 2017Vol: 595, Pages: 1431–1432DOI: 10.1113/JP273739

Comments

Last words by Last words by Rodriguez-Miguelez et al

Last words by Hulzebos et al


CrossTalk debate 31 published 30 June 2016

Metabolic syndrome causes sleep apnoea / Sleep apnoea causes metabolic syndrome

CrossTalk proposal: Metabolic syndrome causes sleep apnoea
Alexandros N. Vgontzas, Jordan Gaines, Silke Ryan, Walter T. McNicholas
Article first published online: 30 JUN 2016 | DOI: 10.1113/JP272114

CrossTalk opposing view: Sleep apnoea causes metabolic syndrome
Craig L. Phillips, Camilla M. Hoyos, Brendon J. Yee, Ronald R. Grunstein
Article first published online: 30 JUN 2016 | DOI: 10.1113/JP272115

Rebuttal from Alexandros N. Vgontzas, Jordan Gaines, Silke Ryan and Walter T. McNicholas
Alexandros N. Vgontzas, Jordan Gaines, Silke Ryan, Walter T. McNicholas
Article first published online: 30 JUN 2016 | DOI: 10.1113/JP272615

Rebuttal from Craig L. Phillips, Camilla M. Hoyos, Brendon J. Yee and Ronald R. Grunstein
Craig L. Phillips, Camilla M. Hoyos, Brendon J. Yee, Ronald R. Grunstein
Article first published online: 30 JUN 2016 | DOI: 10.1113/JP272616

Comments

Last words by Vgontzas et al


CrossTalk debate 30 published 24 March 2016

The middle cerebral artery diameter does/does not change during alterations in arterial blood gases and blood pressure

CrossTalk proposal: The middle cerebral artery diameter does change during alterations in arterial blood gases and blood pressure
Ryan L. Hoiland and Philip N. Ainslie
Article first published online: 24 MAR 2016 | DOI: 10.1113/JP271981

CrossTalk opposing view: The middle cerebral artery diameter does not change during alterations in arterial blood gases and blood pressure
R. Matthew Brothers and Rong Zhang
Article first published online: 24 MAR 2016 | DOI: 10.1113/JP271884

Rebuttal from Ryan L. Hoiland and Philip N. Ainslie
Ryan L. Hoiland and Philip N. Ainslie
Article first published online: 24 MAR 2016 | DOI: 10.1113/JP272241

Rebuttal from R. Matthew Brothers and Rong Zhang
R. Matthew Brothers and Rong Zhang
Article first published online: 24 MAR 2016 | DOI: 10.1113/JP272242

Comments

Last words by Brothers and Zhang


CrossTalk debate 29 published 20 March 2016

Intramyocellular ceramide accumulation does/does not modulate insulin resistance

CrossTalk proposal: Intramyocellular ceramide accumulation does modulate insulin resistance
Scott A. Summers and Bret H. Goodpaster
Article first published online: 20 MAR 2016 | DOI: 10.1113/JP271676

CrossTalk opposing view: Intramyocellular ceramide accumulation does not modulate insulin resistance
Max C. Petersen and Michael J. Jurczak
Article first published online: 20 MAR 2016 | DOI: 10.1113/JP271677

Rebuttal from Scott A. Summers and Bret H. Goodpaster
Scott A. Summers and Bret H. Goodpaster
Article first published online: 20 MAR 2016 | DOI: 10.1113/JP272136

Rebuttal from Max C. Petersen and Michael J. Jurczak
Max C. Petersen and Michael J. Jurczak
Article first published online: 20 MAR 2016 | DOI: 10.1113/JP272137

Comments

Last words by Summers and Goodpaster

Last words by Petersen and Jurczak


CrossTalk debate 28 published 3 February 2016

Interstitial cells are/are not involved and physiologically important in neuromuscular transmission in the gut

CrossTalk proposal: Interstitial cells are involved and physiologically important in neuromuscular transmission in the gut
Kenton M. Sanders, Sean M. Ward and Andreas Friebe
Article first published online: 3 FEB 2016 | DOI: 10.1113/JP271600

CrossTalk Opposing View: Interstitial cells are not involved and physiologically important in neuromuscular transmission in the gut
Raj K Goyal
Article first published online: 3 FEB 2016 | DOI: 10.1113/JP271587

Rebuttal from Kenton M. Sanders, Sean M. Ward and Andreas Friebe
Kenton M. Sanders, Sean M. Ward and Andreas Friebe
Article first published online: 3 FEB 2016 | DOI: 10.1113/JP271971

Rebuttal from Raj K Goyal
Raj K Goyal
Article first published online: 3 FEB 2016 | DOI: 10.1113/JP271972

Comments

Last words by Sanders et al

Last words by Goyal


CrossTalk debate 27 published 14 December 2015 

Heat acclimatization does/does not improve performance in a cool condition

CrossTalk proposal: Heat acclimatization does improve performance in a cool condition
Christopher T. Minson and James D. Cotter
Article first published online: 14 DEC 2015 | DOI: 10.1113/JP270879

CrossTalk opposing view: Heat acclimatization does not improve exercise performance in a cool condition 
Lars Nybo and Carsten Lundby
Article first published online: 14 DEC 2015 | DOI: 10.1113/JP270880

Rebuttal by Christopher T. Minson and James D. Cotter
Christopher T. Minson and James D. Cotter
Article first published online: 14 DEC 2015 | DOI: 10.1113/JP271670

Rebuttal by Lars Nybo and Carsten Lundby
Lars Nybo and Carsten Lundby
Article first published online: 14 DEC 2015 | DOI: 10.1113/JP271668

Comments

Last words by Nybo and Lundby

Last words by Minson and Cotter


CrossTalk debate 26 published 7 December 2015

High intensity interval training does/does not have a role in risk reduction or treatment of disease

CrossTalk proposal: High intensity interval training does have a role in risk reduction or treatment of disease
Ulrik Wisløff, Jeff S. Coombes and Øivind Rognmo
Article first published online: 7 DEC 2015 | DOI: 10.1113/JP271041

CrossTalk opposing view: High intensity interval training does not have a role in risk reduction or treatment of disease
Tanya M. Holloway and Lawrence L. Spriet
Article first published online: 7 DEC 2015 | DOI: 10.1113/JP271039

Rebuttal from Ulrik Wisløff, Jeff Coombes and Øivind Rognmo
Ulrik Wisløff, Jeff S. Coombes and Øivind Rognmo
Article first published online: 7 DEC 2015 | DOI: 10.1113/JP271580

Rebuttal from Tanya M. Holloway and Lawrence L. Spriet
Tanya M. Holloway and Lawrence L. Spriet
Article first published online: 7 DEC 2015 | DOI: 10.1113/JP271581

Comments

Last words by Holloway and Spriet


Cross Talk debate 25 published 15 November 2015

Physiological CO2 exchange can depend on membrane channels

CrossTalk proposal: Physiological CO2 exchange can depend on membrane channels
Gordon J. Cooper, Rossana Occhipinti and Walter F. Boron
Article first published online: 15 NOV 2015 | DOI: 10.1113/JP270059

CrossTalk opposing view: Physiological CO2 exchange does not normally depend on membrane channels
Alzbeta Hulikova, Richard D. Vaughan-Jones, Steven A. Niederer and Pawel Swietach
Article first published online: 15 NOV 2015 | DOI: 10.1113/JP270013

Rebuttal from Gordon J. Cooper, Rossana Occhipinti and Walter F. Boron
Gordon J. Cooper, Rossana Occhipinti and Walter F. Boron
Article first published online: 15 NOV 2015 | DOI: 10.1113/JP27121

Rebuttal from Pawel Swietach, Richard D. Vaughan-Jones, Alzbeta Hulikova and Steven A. Niederer
Pawel Swietach, Richard D. Vaughan-Jones, Alzbeta Hulikova and Steven A. Niederer
Article first published online: 15 NOV 2015 | DOI: 10.1113/JP271240

Comments

Last words by Cooper et al

Last words by Hulikova et al


Cross Talk debate 24 published 1 September 2015
Diffusion limitation of O2 from microvessels into muscle does contribute to the limitation of V̇O2 max

CrossTalk proposal: Diffusion limitation of O2 from microvessels into muscle does contribute to the limitation of V̇O2 max
Peter D. Wagner
J Physiol 593 3757-3758

CrossTalk opposing view: Diffusion limitation of O2 from microvessels into muscle does not contribute to the limitation of V̇O2 max
Carsten Lundby and David Montero
J Physiol 593 3759–3761

Rebuttal from Peter D. Wagner
Peter D. Wagner
J Physiol 593 3763

Rebuttal from Carsten Lundby and David Montero
Carsten Lundby and David Montero
J Physiol 593 3765

Comments

Last words by Lundby and Montero

Last words by Wagner


Cross Talk debate 23 published 1 August 2015
5-HT is necessary for peristalsis

CrossTalk proposal: 5-HT is necessary for peristalsis
Terence K. Smith and Michael D. Gershon
J Physiol 593 3225–3227

CrossTalk opposing view: 5-HT is not necessary for peristalsis
Nick J. Spencer, Tiong Cheng Sia, Simon J Brookes, Marcello Costa and Damien J. Keating
J Physiol 593 3229–3231

Rebuttal from Terence K. Smith and Michael D. Gershon
Terence K. Smith and Michael D. Gershon
J Physiol 593 3233

Rebuttal from Nick J. Spencer, Tiong Cheng Sia, Simon J Brookes, Marcello Costa and Damien J. Keating
Nick J. Spencer, Tiong Cheng Sia, Simon J Brookes, Marcello Costa and Damien J. Keating
J Physiol 593 3235

Comments

Last words by Smith and Gershon

Last words by Spencer et al


Cross Talk debate 22 published 15 July 2015

Fear of falling does influence vestibular-evoked balance responses

CrossTalk proposal: Fear of falling does influence vestibular-evoked balance responses
Brian C. Horslen, Christopher J. Dakin, J. Timothy Inglis, Jean-Sébastien Blouin and Mark G. Carpenter
J Physiol 593 2979-2981

Crosstalk opposing view: Fear of falling does not influence vestibular-evoked balance responses
Raymond F. Reynolds, Callum J. Osler, M. C. A. Tersteeg and Ian D. Loram
J Physiol 593 2983-2984

Rebuttal from Brian C. Horslen, Christopher J. Dakin, J. Timothy Inglis, Jean-Sébastien Blouin and Mark G. Carpenter
Brian C. Horslen, Christopher J. Dakin, J. Timothy Inglis, Jean-Sébastien Blouin and Mark G. Carpenter
J Physiol 593 2985

Rebuttal from Raymond Reynolds, Callum Osler, Linda Tersteeg and Ian Loram
Raymond F. Reynolds, Callum J. Osler, M. C. A. Tersteeg and Ian D. Loram
J Physiol 593 2987

Comments

Last words by Carpenter et al

Last words by Loram et al


Cross Talk debate 21 published 15 April 2015

Bradycardia in the trained athlete is attributable to high vagal tone

CrossTalk proposal: Bradycardia in the trained athlete is attributable to high vagal tone
John H. Coote and Michael J. White
J Physiol 5931745-1747

CrossTalk opposing view: Bradycardia in the trained athlete is attributable to a downregulation of a pacemaker channel in the sinus node
Alicia D'Souza, Sanjay Sharma and Mark R. Boyett
J Physiol 593,1749–1751

Rebuttal from John H. Coote and Michael J. White
John H. Coote and Michael J. White
J Physiol 593, 1753

Rebuttal from Alicia D'Souza, Sanjay Sharma and Mark R. Boyett
Alicia D'Souza, Sanjay Sharma and Mark R. Boyett
J Physiol 593, 1755

Comments

Last words by Coote and White

Last words by Boyett et al


CrossTalk debate 20 published 15 December 2014

The dominant mechanism causing disuse muscle atrophy is decreased protein synthesis/proteolysis

CrossTalk proposal: The dominant mechanism causing disuse muscle atrophy is decreased
protein synthesis

Stuart M. Phillips SM & Chris McGlory C (2014)
J Physiol 592, 5341–5343

CrossTalk opposing view: The dominant mechanism causing disuse muscle atrophy is proteolysis
Reid MB, Judge AR & Bodine SC (2014)
J Physiol 592, 5345–5347

Rebuttal from Stuart M. Phillips and Chris McGlory
Phillips SM & McGlory C (2014)
J Physiol 592, 5349

Rebuttal from Michael B. Reid, Andrew R. Judge and Sue C. Bodine
Reid MB, Judge AR & Bodine SC (2014)
J Physiol 592, 5351

Comments 

Last Word from Stuart M. Phillips and Chris McGlory

Last Word from Michael B. Reid, Andrew R. Judge and Sue C. Bodine


CrossTalk debtate 19 published 1 December 2014

De novo capillary recruitment in healthy muscle is/is not necessary to explain physiological outcomes

CrossTalk proposal: De novo capillary recruitment in healthy muscle is necessary
Barrett EJ, Keske MA, Rattigan S & Eringa EC (2014)
J Physiol 592, 5129–5131.

CrossTalk opposing view: De novo capillary recruitment in healthy muscle is not necessary to explain physiological outcomes
Poole DC (2014)
J Physiol 592, 5133–5135

Rebuttal from Eugene J. Barrett, Michelle A. Keske, Stephen Rattigan and Etto C. Eringa
Barrett EJ, Keske MA, Rattigan S & Eringa EC (2014)
J Physiol 592, 5137–5138

Rebuttal from David C. Poole
Poole DC (2014)
J Physiol 592, 5139

Comments 

Last Words from David C. Poole and Eugene J. Barrett, Michelle A. Keske, Stephen Rattigan and Etto C. Eringa


CrossTalk debate 18 published 15 September 2014

Which technique for controlling resistant hypertension?

CrossTalk opposing view: Which technique for controlling resistant hypertension? Carotid sinus stimulation
Jordan J (2014)
J Physiol 592, 3933–3935

CrossTalk opposing view: Which technique for controlling resistant hypertension? Renal nerve ablation
Schlaich MP, Sata Y & Esler MD (2014)
J Physiol 592, 3937–3940

CrossTalk opposing view: Which technique for controlling resistant hypertension? Carotid chemoreceptor denervation/modulation
Ratcliffe LEK, Pijacka W, McBryde FD, Abdala AP, Moraes DJ, Sobotka PA, Hart EC, Narkiewicz K, Nightingale AK & Paton JFR (2014)
J Physiol 592, 3941–3944

Rebuttal from Jens Jordan
Jordan J (2014)
J Physiol 592, 3945

Rebuttal from Markus P. Schlaich, Yusuke Sata and Murray D. Esler
Schlaich MP, Sata Y & Esler MD (2014)
J Physiol 592, 3947

Rebuttal from L. E. K. Ratcliffe, W. Pijacka, F. D. McBryde, A. P. Abdala, D. J. Moraes, P. A. Sobotka, E. C. Hart, K. Narkiewicz, A. K. Nightingale and J. F. R. Paton
Ratcliffe LEK, Pijacka W, McBryde FD, Abdala AP, Moraes DJ, Sobotka PA, Hart EC, Narkiewicz K, Nightingale AK & Paton JFR (2014)
J Physiol 592, 3949–3950

Comments

Last Word from Jens Jordan

Last Word from L. E. K. Ratcliffe, W. Pijacka, F. D. McBryde, A. P. Abdala, D. J. Moraes, P. A. Sobotka, E. C. Hart, K. Narkiewicz, A. K. Nightingale and J. F. R. Paton


CrossTalk debate 17 published 1 August 2014

Rotors have/have not been demonstrated to drive human atrial fibrillation

CrossTalk proposal: Rotors have been demonstrated to drive human atrial fibrillation
Narayan SM & Jalife J (2014)
J Physiol 592, 3163–3166

CrossTalk opposing view: Rotors have not been demonstrated to be the drivers of atrial fibrillation
Maurits Allessie M & Natasja de Groot N (2014)
J Physiol 592, 3167–3170

Rebuttal from Sanjiv M. Narayan and José Jalife
Sanjiv M. Narayan SM & José Jalife J (2014)
J Physiol 592, 3171

Rebuttal from Maurits Allessie and Natasja de Groot
Allessie M & de Groot N (2014)
J Physiol 592, 3173

Comments

Last Word from Maurits Allessie

Last Word from Jose Jalife and Sanjiv M. Narayan


CrossTalk debate 16 published 15 July 2014

Elevated loop gain is/is not a consequence of obstructive sleep apnoea

CrossTalk proposal: Elevated loop gain is a consequence of obstructive sleep apnoea
Younes M (2014)
J Physiol 592, 2899–2901

CrossTalk opposing view: Loop gain is not a consequence of obstructive sleep apnoea
Orr JE, Edwards BA & Malhotra A (2014)
J Physiol 592, 2903–2905

Rebuttal from Magdy Younes
Younes M (2014)
J Physiol 592, 2907–2908

Rebuttal from J. E. Orr, B. A. Edwards and A. Malhotra
Orr JE, Edwards BA & Malhotra A (2014)
J Physiol 592, 2909

Comments

Last Word from J. E. Orr, B. A. Edwards and A. Malhotra

Last Word from Magdy Younes


CrossTalk debate 15 published 15 June 2014

Weighing the evidence for Class A GPCR dimers, the evidence favours dimers/the jury is still out

CrossTalk proposal: Weighing the evidence for Class A GPCR dimers, the evidence favours dimers
Bouvier M & Hébert TE (2014)
J Physiol592, 2439–2441

CrossTalk opposing view: Weighing the evidence for class A GPCR dimers, the jury is still out
Lambert NA & Javitch JA (2014)
J Physiol592, 2443–2445

Rebuttal from Michel Bouvier and Terence E. Hébert
Bouvier M & Hébert TE (2014)
J Physiol592, 2447

Rebuttal from Nevin A. Lambert and Jonathan A. Javitch
Lambert NA & Javitch JA (2014)
J Physiol592, 2449

Comments

Last Word from Terence E. Hebert and Michel Bouvier

Last Word from Nevin A. Lambert and Jonathan A. Javitch


CrossTalk debate 14 published 15 March 2014

The preBötzinger complex is/is not essential for the respiratory depression following systemic administration of opioid analgesics

CrossTalk proposal: The preBötzinger complex is essential for the respiratory depression following systemic administration of opioid analgesics
Montandon G & Horner R (2014)
J Physiol 592, 1159–1162

CrossTalk opposing view: The pre-Bötzinger complex is not essential for respiratory depression following systemic administration of opioid analgesics
Lalley PM, Pilowsky PM, Forster HV & Zuperku EJ (2014)
J Physiol 592, 1163–1166

Rebuttal from Gaspard Montandon and Richard Horner
Montandon G & Horner R (2014)
J Physiol 592, 1167

Rebuttal from Peter M. Lalley, Paul M. Pilowsky, Hubert V. Forster and Edward J. Zuperku
Lalley PM, Pilowsky PM, Forster HV & Zuperku EJ (2014)
J Physiol 592, 1169

Comments

Last Word from Peter M. Lalley, Paul M. Pilowsky, Hubert V. Forster and Edward J. Zuperku

Last Word from Gaspard Montandon and Richard Horner


CrossTalk debate 13 published 1 February 2014

The late sodium current is/is not an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction)

CrossTalk proposal: The late sodium current is an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction)
Pourrier M, Williams S, McAfee D, Belardinelli L & Fedida D (2014)
J Physiol 592, 411–414

CrossTalk opposing view: The late sodium current is not an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction)
Papp Z, Borbély A & Paulus WJ (2014)
J Physiol 592, 415–417

Rebuttal from Marc Pourrier, Sarah Williams, Donald McAfee, Luiz Belardinelli and David Fedida
Pourrier M, Williams S, McAfee D, Belardinelli L & Fedida D (2014)
J Physiol 592, 419

Rebuttal from Zoltán Papp, Attila Borbély and Walter J. Paulus
Papp Z, Borbély A & Paulus WJ (2014)
J Physiol 592, 421–422

Comments

Last Word from Pourrier et al.

Last Word from Papp et al.


CrossTalk debate 12 published 15 December 2013

Cell volume changes are/are not an essential step in the cell death machinery

CrossTalk proposal: Cell volume changes are an essential step in the cell death machinery
Lang F & Hoffmann EK (2013)
J Physiol 591, 6119–6121

CrossTalk opposing view: the triggering and progression of the cell death machinery can occur without cell volume perturbations
Orlov SN, Model MA & Grygorczyk R (2013)
J Physiol 591, 6123–6125

Rebuttal from Florian Lang and Else K. Hoffmann
Lang F & Hoffmann EK (2013)
J Physiol 591, 6127

Rebuttal from Sergei N. Orlov, Michael M. Model and Ryszard Grygorczyk
Orlov SN, Model MA & Grygorczyk R (2013)
J Physiol 591, 6129

Comments

Last Word from Lang and Hoffmann

Last Word from Model


CrossTalk debate 11 published 1 December 2013

Guyton's venous return curves should/should not be taught

CrossTalk proposal: Guyton's venous return curves should be taught
Andrew P (2013)
J Physiol 591, 5791–5793

CrossTalk opposing view: Guyton's venous return curves should not be taught
Beard DA & Feigl EO (2013)
J Physiol 591, 5795–5797

Rebuttal from Philip Andrew
Andrew P (2013)
J Physiol 591, 5799

Rebuttal from Daniel Beard and Eric Feigl
Beard DA & Feigl EO (2013)
J Physiol 591, 5801

Comments

Last Word from Andrew

Last Word from Beard and Feigl


CrossTalk debate 10 published 1 November 2013

The diaphragm muscle does/does not atrophy as a result of inactivity

CrossTalk proposal: Mechanical ventilation-induced diaphragm atrophy is primarily due to inactivity
Powers SK, Smuder AJ, Fuller D & Levine S (2013)
J Physiol 591, 5255–5257

CrossTalk opposing view: The diaphragm muscle does not atrophy as a result of inactivity
Sieck GC & Mantilla CB (2013)
J Physiol 591, 5259–5262

Rebuttal from Scott K. Powers, Ashley J. Smuder, David Fuller and Sanford Levine
Powers SK, Smuder AJ, Fuller D & Levine S (2013)
J Physiol 591, 5263

Rebuttal from Gary C. Sieck and Carlos B. Mantilla
Sieck GC & Mantilla CB (2013)
J Physiol 591, 5265

Comments

Last Word from Powers et al.

Last Word from Sieck & Mantilla


CrossTalk debate 9 published 15 October 2013

Prolonged intense exercise training does/does not lead to myocardial damage

CrossTalk proposal: Prolonged intense exercise training does lead to myocardial damage
Guasch E & Nattel S (2013)
J Physiol 591, 4939–4941

CrossTalk opposing view: Prolonged intense exercise does not lead to cardiac damage
Ruiz JR, Joyner M & Lucia A (2013)
J Physiol 591, 4943–4945

Rebuttal from Eduard Guasch and Stanley Nattel
Guasch E & Nattel S (2013)
J Physiol 591, 4947

Rebuttal from Jonatan R. Ruiz, Michael Joyner and Alejandro Lucia
Ruiz JR, Joyner M and Lucia A (2013)
J Physiol 591, 4949

Comments

Last words from Joyner, Ruiz, Guasch, Nattel and Lucia


CrossTalk debate 8 published 15 September 2013

Peripheral and central chemoreflexes have additive/ hypoadditive/ hyperadditive effects on ventilation in humans

CrossTalk opposing view: Peripheral and central chemoreflexes have additive effects on ventilation in humans
Duffin J & Mateika JH (2013)
J Physiol 591, 4351–4353

CrossTalk opposing view: Peripheral and central chemoreceptors have hypoadditive effects on respiratory motor output
Wilson RJA & Day TA (2013)
J Physiol 591, 4355–4357

CrossTalk opposing view: Peripheral and central chemoreceptors have hyperadditive effects on respiratory motor control
Teppema LJ & Smith CA (2013)
J Physiol 591, 4359–4361

Rebuttal from James Duffin and Jason H. Mateika
Duffin J & Mateika JH (2013)

J Physiol591, 4363

Rebuttal by Richard J. A. Wilson and Trevor A. Day
Wilson RJA & Day TA (2013)
J Physiol 591, 4365

Rebuttal from Luc J. Teppema and Curtis A. Smith
Teppema LJ & Smith CA (2013)
J Physiol 591, 4367

Comments

Last Word from Duffin and Mateika

Last Word from Wilson and Day

Last Word from Teppema and Smith


CrossTalk debate 7 published 1 June 2013

There is/there is not added benefit to providing permissive hypercapnia in the treatment of ARDS

CrossTalk proposal: There is added benefit to providing permissive hypercapnia in the treatment of ARDS
Curley GF, Laffey JG & Kavanagh BP
J Physiol 591, 2763–2765 (2013)

CrossTalk opposing view: There is not added benefit to providing permissive hypercapnia in the treatment of ARDS
Beitler JR, Hubmayr RD & Malhotra A
J Physiol 591, 2767–2769 (2013)

Rebuttal from Gerard F. Curley, John G. Laffey and Brian P. Kavanagh
Curley GF, Laffey JG & Kavanagh BP
J Physiol 591, 2771–2772 (2013)

Rebuttal from Jeremy R. Beitler, Rolf D. Hubmayr and Atul Malhotra
Beitler JR, Hubmayr RD & Malhotra A
J Physiol 591, 2773 (2013)

Comments

Last Word from G. F. Curley et al.

Last Word from R. Beitleret al.


CrossTalk debate 6 published 1 May 2013

The human upper airway does/does not behave like a Starling resistor during sleep

CrossTalk proposal: The human upper airway does behave like a Starling resistor during sleep
Schwartz AR & Smith PL
J Physiol 591, 2229–2232 (2013)

CrossTalk opposing view: The human upper airway during sleep does not behave like a Starling resistor
Butler JP, Owens RL, Malhotra A & Wellman A
J Physiol 591, 2233–2234 (2013)

Rebuttal from Alan R. Schwartz and Philip L. Smith
Schwartz AR & Smith PL
J Physiol 591, 2235 (2013)

Rebuttal from James P. Butler, Robert L. Owens, Atul Malhotra and Andrew Wellman
Butler JP, Owens RL, Malhotra A & Wellman A
J Physiol 591, 2237 (2013)

Comments

Last Word


CrossTalk debate 5 published 1 April 2013

TARPs modulate AMPA receptor gating transitions/AMPA receptor conformations before the gating transitions

CrossTalk proposal: TARPs modulate AMPA receptor gating transitions
Howe JR
J Physiol 591, 1581–1583 (2013)

CrossTalk opposing view: TARPs modulate AMPA receptor conformations before the gating transitions
MacLean DM
J Physiol 591, 1585–1586 (2013)

Rebuttal from James Howe
Howe JR
J Physiol 591, 1587 (2013)

Rebuttal from David M. MacLean
MacLean DM
J Physiol 591, 1589 (2013)

Comments

Last Word


CrossTalk debate 4 published 1 March 2013

Forward and backward pressure waves in the arterial system do/do not represent reality

CrossTalk proposal: Forward and backward pressure waves in the arterial system do represent reality
Nico Westerhof and Berend E. Westerhof
J Physiol 591, 1167–1169 (2013)

CrossTalk opposing view: Forward and backward pressure waves in the arterial system do not represent reality
John V. Tyberg, J. Christopher Bouwmeester, Nigel G. Shrive, and Jiun-Jr Wang
J Physiol 591, 1171–1173 (2013)

Rebuttal from Nico Westerhof and Berend E. Westerhof
Nico Westerhof and Berend E. Westerhof
J Physiol 591, 1175 (2013)

Rebuttal from John V. Tyberg, J. Christopher Bouwmeester, Nigel G. Shrive and Jiun-Jr Wang
John V. Tyberg, J. Christopher Bouwmeester, Nigel G. Shrive, and Jiun-Jr Wang
J Physiol 591, 1177 (2013)

Comments

Last Word from Westerhof & Westerhof

Last Word from Tyberg et al.


CrossTalk debate 3 published 15 January 2013

The intermittent hypoxia attending severe obstructive sleep apnoea does/does not lead to alterations in brain structure and function

CrossTalk proposal: The intermittent hypoxia attending severe obstructive sleep apnoea does lead to alterations in brain structure and function
David Gozal
J Physiol 591, 379–381 (2013)

CrossTalk opposing view: The intermittent hypoxia attending severe obstructive sleep apnoea does not lead to alterations in brain structure and function
Ivana Rosenzweig, Steven C. Williams, and Mary J. Morrell
J Physiol 591, 383–385 (2013)

Rebuttal from David Gozal
David Gozal
J Physiol 591, 387 (2013)

Rebuttal from Ivana Rosenzweig, Steven C. Williams and Mary J. Morrell
Ivana Rosenzweig, Steven C. Williams, and Mary J. Morrell
J Physiol 591, 389 (2013)

Comments

Last Word


CrossTalk debate 2 published 1 August 2012

Training the respiratory muscles does/does not improve exercise tolerance

CrossTalk proposal: Training the respiratory muscles does not improve exercise tolerance
Mehul S. Patel, Nicholas Hart, and Michael I. Polkey
J Physiol 590, 3393–3395 (2012)

CrossTalk opposing view: Respiratory muscle training does improve exercise tolerance
Alison K. McConnell
J Physiol 590, 3397–3398 (2012)

Rebuttal from Mehul S. Patel, Nicholas Hart and Michael I. Polkey
Mehul S. Patel, Nicholas Hart, and Michael I. Polkey
J Physiol 590, 3399–3400 (2012)

Rebuttal from Alison K. McConnell
Alison K. McConnell
J Physiol 590, 3401 (2012)

Comments

Last Word


CrossTalk debate 1 published 15 June 2012

Most of the cardiovascular consequences of OSA are/are not due to increased sympathetic activity

CrossTalk proposal: Most of the cardiovascular consequences of OSA are due to increased sympathetic activity
Malcolm Kohler and John R. Stradling
J Physiol 590, 2813–2815 (2012)

CrossTalk opposing view: Most cardiovascular diseases in sleep apnoea are not caused by sympathetic activation
Lena Lavie and Peretz Lavie
J Physiol 590, 2817–2819 (2012)

Rebuttal from Malcolm Kohler and John R. Stradling
Malcolm Kohler and John R. Stradling
J Physiol 590, 2821 (2012)

Rebuttal from Lena Lavie and Peretz Lavie
Lena Lavie and Peretz Lavie
J Physiol 590, 2823 (2012)

Comments

Last words by Lavie and Lavie

Funder Compliance

Editor's Choice

15 October  - Volume 595 Issue 20

The kindlin-2 double act

Xi Ye, Kim A. Dora

Kindlin-2 interacts with endothelial adherens junctions to support vascular barrier integrity

Elzbieta Pluskota, Kamila M. Bledzka, Katarzyna Bialkowska, Dorota Szpak, Dmitry A. Soloviev, Sidney V. Jones, Dmitriy Verbovetskiy, Edward F. Plow

Chronic morphine reduces the readily releasable pool of GABA, a presynaptic mechanism of opioid tolerance

Adrianne R. Wilson‐Poe, Hyo‐Jin Jeong, Christopher W. Vaughan

Median preoptic glutamatergic neurons promote thermoregulatory heat loss and water consumption in mice

Stephen B. G. Abbott, Clifford B. Saper

See all »

Experimental Biology joint virtual issue 2017

Joint Virtual Issue - Experimental Biology 2017

Reflecting the increasingly interdisciplinary nature of life science research, this collection brings together articles published in the journals of the Biochemical Society, the British Pharmacological Society, ASPET and The Physiological Society. Key topics highlighted include neurobiology, gastrointestinal biology, obesity, nutrition, and epigenetics.

All articles are free to read until 31 May. We hope you enjoy our collection!


Neurobiology

The repair Schwann cell and its function in regenerating nerves
The Journal of Physiology | K. R. Jessen & R. Mirsky | 10.1113/JP270874

What do we really know about newborn infant pain?
Experimental Physiology | Maria Fitzgerald | 10.1113/EP085134

Retrograde apoptotic signaling by the p75 neurotrophin receptor
Neuronal Signaling | Amrita Pathak & Bruce D. Carter  | 10.1042/NS20160007

Extracellular matrix inflammation in vascular cognitive impairment and dementia
Clinical Science | Gary A. Rosenberg | 10.1042/CS20160604

Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction
Biochemical Journal | Paul Bishop et al | 10.1042/BCJ20160082

Relaxin’ the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders
British Journal of Clinical Pharmacology | Jigna Rajesh Kumar et al | 10.1111/bph.13564

Pharmacological comparison of a nonhuman primate and a rat model of oxaliplatin-induced neuropathic cold hypersensitivity
Pharmacology Research & Perspectives |Yuka Shidahara et al | 10.1002/prp2.216


Gastrointestinal biology

Endogenous and exogenous control of gastrointestinal epithelial function: building on the legacy of Bayliss and Starling
The Journal of Physiology | Kim E. Barrett | 10.1113/JP272227

Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in Sprague–Dawley rats
Experimental Physiology | Maria M. Buckleyet al | 10.1113/EP085917

Gastrointestinal transport of calcium and glucose in lactating ewes
Physiological Reports | Stefanie Klinger et al | 10.14814/phy2.12817

Foxa2 and Hif1ab regulate maturation of intestinal goblet cells by modulating agr2 expression in zebrafish embryos
Biochemical Journal | Yun-Ren Lai et al| 10.1042/BCJ20160392

Age-associated modifications of intestinal permeability and innate immunity in human small intestine
Clinical Science | Angela L. Mani et al|10.1042/CS20150046

Prescription behavior for gastroprotective drugs in new users as a result of communications regarding clopidogrel – proton pump inhibitor interaction
Pharmacology Research & Perspectives | Willemien J. Kruik-Kollöffel et al| 10.1002/prp2.242

Octreotide s.c. depot provides sustained octreotide bioavailability and similar IGF-1 suppression to octreotide LAR in healthy volunteers
British Journal of Clinical Pharmacology | F Tiberg et al| 10.1111/bcp.12698

Hydrogen sulphide protects against NSAID-enteropathy through modulation of bile and the microbiota
British Journal of Pharmocology |RW Blackler et al| 10.1111/bph.12961


Obesity

Resveratrol supplementation of high-fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring
The Journal of Physiology | Tiande Zou et al | 10.1113/JP273478

Oxidative stress and immunosenescence in spleen of obese mice can be reversed by 2-hydroxyoleic acid
Experimental Physiology | Alina Gheorghe et al | 10.1113/EP086157

Similar degrees of obesity induced by diet or aging cause strikingly different immunologic and metabolic outcomes
Physiological Reports | Kanthi B. Krishna at al | 0.14814/phy2.12708

Energy balalance, body composition, sedentariness and appetite regulation: pathways to obesity
Clinical Sciences | Mark Hopkins et al | 10.1042/CS20160006

New insight on obesity and adipose-derived stem cells using comprehensive metabolomics
Biochemical Journal |Annalaura Mastrangelo at al | 10.1042/BCJ20160241

A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes
Pharmacology Research & Perspectives | Yanyun Chen et al | 10.1002/prp2.278

The effectiveness of pharmaceutical interventions for obesity: weight loss with orlistat and sibutramine in a United Kingdom population-based cohort
British Journal of Clinical Pharmocology | IJ Douglas et al | 10.1111/bcp.12578

Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning
British Journal of Pharmocology | TM Henagan at al | 10.1111/bph.13058


Nutrition

Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers
The Journal of Physiology | Louise M. Burke et al | 10.1113/JP273230

Long term dietary quercetin enrichment as a cardioprotective countermeasure in mdx mice
Experimental Physiology | Christopher Ballmannl et al | 10.1113/EP086091

Undernutrition in pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring
Bioscience Reports |Brittany Beauchamp et al | 10.1042/BSR20150007

Blood triacylglycerols: a lipidomic window on diet and disease
Biochemical Society Transactions | Francis Saunders et al | 10.1042/BST20150235

The potential health effects of dietary phytoestrogens
British Journal of Pharmocology | Ivonne M C M Rietjens at al | 10.1111/bph.13622

Mediterranean diet, dietary polyphenols and low grade inflammation: results from the MOLI-SANI study
British Journal of Clinical Pharmocology |Marialaura Bonaccio at al | 10.1111/bcp.12924


Epigenetics

Late gestational intermittent hypoxia induces metabolic and epigenetic changes in male adult offspring mice
The Journal of Physiology |Abdelnaby Khalyfa et al | 10.1113/JP273570

Multigenerational effects of fetal-neonatal iron deficiency on hippocampal BDNF signaling
Physiological Reports | Mariah B. Blegen et al | 10.1002/phy2.96

Epigenetic inheritance of proteostasis and ageing
Essays in Biochemistry | Cheryl Li & Olivia Casanueva | 10.1042/EBC20160025

Epigenetic regulation of skeletal muscle metabolism
Clinical Science | Kirsten F Howlet &, Sean L McGee | 10.1042/CS20160115

A saga of cancer epigenetics: linking epigenetics to alternative splicing
Biochemical Journal| Sathiya Pandi Narayanan et al | 10.1042/BCJ20160147

Downregulation of the Ca2+-activated K+ channel KCa3.1 by histone deacetylase inhibition in human breast cancer cells
Pharmacology Research & Perspectivesl | Susumu Ohya et al | 10.1002/prp2.228

Therapeutic perspectives of epigenetically active nutrients
British Journal of Pharmocology | M Remely et al | 10.1111/bph.12854