Prof Mike Tipton Reddit 'AMA'| Extreme Physiology!
Mike Tipton, Editor-in-Chief of Experimental Physiology Professor of Human & Applied Physiology at the Extreme Environments Laboratory at the University of Portsmouth will be doing a 'Ask me anything' session on Reddit.
AMAs (short for Ask Me Anything) were created by the Reddit community as an opportunity for individuals to field questions about anything. The Reddit Science community (known as /r/Science) have an independent, science-focused AMA Series where individuals can have a candid conversation with the large and diverse Reddit Science community.
To access and and participate in the AMA, you will need to navigate to www.reddit.com/r/science on Tuesday 19 December, 4:00pm GMT (11:00am EST).
AMA session description:
I'm Mike Tipton, Professor of Human & Applied Physiology at the Extreme Environments Laboratory, University of Portsmouth and Editor-in-Chief of Experimental Physiology. I'm happy to talk about extreme physiology, how to get your paper published and anything else of relevance to Experimental Physiology and research. AMA!
Only 15% of the surface of the Earth is not water, desert, ice or mountain. For humans, a tropical, low altitude, air-breathing animal, this means most of the planet represents a hostile or extreme environment. Extreme environmental physiology covers a wide range of topics including: physiologically preparing groups such as elite athletes to try and maintain high level performance in hot and cold environments, using strategies such as acclimatisation; considering using altitude training and heat acclimation as ergogenic aids to enhance performance in temperate sea level conditions; determining the benefit of cross-adaptation between one extreme environment and another; protecting, via technological solutions (e.g. personal protective equipment), those who, as part of their work or play, enter extreme environments (e.g. astronauts, divers, firefighters, sailors, the military).
Our habitation of the planet has been largely enabled by technological advances (clothing, shelter, heating) founded on intellect. But sometimes this technology goes wrong requiring extreme environmental research related to accidental exposures and the consequent pathophysiology of heat illness, cold injury, hypothermia; hypoxia, barotrauma and drowning. These are not just “niche issues”; forty-three people around the globe drown each hour. These are mostly young people and this figure is an under-estimation.
Finally, research in extreme environments such as microgravity and hypoxia is also shedding new light on areas such as ageing, body tissue wasting and outcome in critical illness. If any of the above interests you, let’s chat on the 19th December 4-6pm (GMT).
Monthly Editor’s pick
December - Volume 102 Issue 12
Michael M. Tymko, Thijs P. Kerstens, Kevin W. Wildfong and Philip N. Ainslie
Marcus Vinicius Machado, Aline Bomfim Vieira, Fabiana Gomes da Conceição, Alessandro Rodrigues Nascimento, Antonio Claudio Lucas da Nóbrega and Eduardo Tibirica
Stay Connected to Experimental Physiology
Joint Virtual Issue - Experimental Biology 2017
Reflecting the increasingly interdisciplinary nature of life science research, this collection brings together articles published in the journals of the Biochemical Society, the British Pharmacological Society, ASPET and The Physiological Society. Key topics highlighted include neurobiology, gastrointestinal biology, obesity, nutrition, and epigenetics.
All articles are free to read until 31 May. We hope you enjoy our collection!
The repair Schwann cell and its function in regenerating nerves
The Journal of Physiology | K. R. Jessen & R. Mirsky | 10.1113/JP270874
What do we really know about newborn infant pain?
Experimental Physiology | Maria Fitzgerald | 10.1113/EP085134
Retrograde apoptotic signaling by the p75 neurotrophin receptor
Neuronal Signaling | Amrita Pathak & Bruce D. Carter | 10.1042/NS20160007
Extracellular matrix inflammation in vascular cognitive impairment and dementia
Clinical Science | Gary A. Rosenberg | 10.1042/CS20160604
Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction
Biochemical Journal | Paul Bishop et al | 10.1042/BCJ20160082
Relaxin’ the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders
British Journal of Clinical Pharmacology | Jigna Rajesh Kumar et al | 10.1111/bph.13564
Pharmacological comparison of a nonhuman primate and a rat model of oxaliplatin-induced neuropathic cold hypersensitivity
Pharmacology Research & Perspectives |Yuka Shidahara et al | 10.1002/prp2.216
Endogenous and exogenous control of gastrointestinal epithelial function: building on the legacy of Bayliss and Starling
The Journal of Physiology | Kim E. Barrett | 10.1113/JP272227
Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in Sprague–Dawley rats
Experimental Physiology | Maria M. Buckleyet al | 10.1113/EP085917
Gastrointestinal transport of calcium and glucose in lactating ewes
Physiological Reports | Stefanie Klinger et al | 10.14814/phy2.12817
Foxa2 and Hif1ab regulate maturation of intestinal goblet cells by modulating agr2 expression in zebrafish embryos
Biochemical Journal | Yun-Ren Lai et al| 10.1042/BCJ20160392
Age-associated modifications of intestinal permeability and innate immunity in human small intestine
Clinical Science | Angela L. Mani et al|10.1042/CS20150046
Prescription behavior for gastroprotective drugs in new users as a result of communications regarding clopidogrel – proton pump inhibitor interaction
Pharmacology Research & Perspectives | Willemien J. Kruik-Kollöffel et al| 10.1002/prp2.242
Octreotide s.c. depot provides sustained octreotide bioavailability and similar IGF-1 suppression to octreotide LAR in healthy volunteers
British Journal of Clinical Pharmacology | F Tiberg et al| 10.1111/bcp.12698
Hydrogen sulphide protects against NSAID-enteropathy through modulation of bile and the microbiota
British Journal of Pharmocology |RW Blackler et al| 10.1111/bph.12961
Resveratrol supplementation of high-fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring
The Journal of Physiology | Tiande Zou et al | 10.1113/JP273478
Oxidative stress and immunosenescence in spleen of obese mice can be reversed by 2-hydroxyoleic acid
Experimental Physiology | Alina Gheorghe et al | 10.1113/EP086157
Similar degrees of obesity induced by diet or aging cause strikingly different immunologic and metabolic outcomes
Physiological Reports | Kanthi B. Krishna at al | 0.14814/phy2.12708
Energy balalance, body composition, sedentariness and appetite regulation: pathways to obesity
Clinical Sciences | Mark Hopkins et al | 10.1042/CS20160006
New insight on obesity and adipose-derived stem cells using comprehensive metabolomics
Biochemical Journal |Annalaura Mastrangelo at al | 10.1042/BCJ20160241
A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes
Pharmacology Research & Perspectives | Yanyun Chen et al | 10.1002/prp2.278
The effectiveness of pharmaceutical interventions for obesity: weight loss with orlistat and sibutramine in a United Kingdom population-based cohort
British Journal of Clinical Pharmocology | IJ Douglas et al | 10.1111/bcp.12578
Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning
British Journal of Pharmocology | TM Henagan at al | 10.1111/bph.13058
Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers
The Journal of Physiology | Louise M. Burke et al | 10.1113/JP273230
Long term dietary quercetin enrichment as a cardioprotective countermeasure in mdx mice
Experimental Physiology | Christopher Ballmannl et al | 10.1113/EP086091
Undernutrition in pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring
Bioscience Reports |Brittany Beauchamp et al | 10.1042/BSR20150007
Blood triacylglycerols: a lipidomic window on diet and disease
Biochemical Society Transactions | Francis Saunders et al | 10.1042/BST20150235
The potential health effects of dietary phytoestrogens
British Journal of Pharmocology | Ivonne M C M Rietjens at al | 10.1111/bph.13622
Mediterranean diet, dietary polyphenols and low grade inflammation: results from the MOLI-SANI study
British Journal of Clinical Pharmocology |Marialaura Bonaccio at al | 10.1111/bcp.12924
Late gestational intermittent hypoxia induces metabolic and epigenetic changes in male adult offspring mice
The Journal of Physiology |Abdelnaby Khalyfa et al | 10.1113/JP273570
Multigenerational effects of fetal-neonatal iron deficiency on hippocampal BDNF signaling
Physiological Reports | Mariah B. Blegen et al | 10.1002/phy2.96
Epigenetic inheritance of proteostasis and ageing
Essays in Biochemistry | Cheryl Li & Olivia Casanueva | 10.1042/EBC20160025
Epigenetic regulation of skeletal muscle metabolism
Clinical Science | Kirsten F Howlet &, Sean L McGee | 10.1042/CS20160115
A saga of cancer epigenetics: linking epigenetics to alternative splicing
Biochemical Journal| Sathiya Pandi Narayanan et al | 10.1042/BCJ20160147
Downregulation of the Ca2+-activated K+ channel KCa3.1 by histone deacetylase inhibition in human breast cancer cells
Pharmacology Research & Perspectivesl | Susumu Ohya et al | 10.1002/prp2.228
Therapeutic perspectives of epigenetically active nutrients
British Journal of Pharmocology | M Remely et al | 10.1111/bph.12854