Early Investigator Prize 

The Journal of Physiology is pleased to offer an Early Investigator Prize. This initiative is designed to reward early career authors who publish outstanding research papers in The Journal. It is sponsored by both The Journal and our publishers Wiley-Blackwell.

The winning entries for this prize will be announced in The Journal of Physiology, on The Journal’s website and in Physiology News. The presentation of the 2016 winners will be made in 2017.

  • Applications are invited from scientists who are authors of a research article published in The Journal of Physiology during the prize year;
  • Entrants can be PhD students;
  • Entrants must have received their research degree (MD, PhD or equivalent) less than 6 years before submitting a paper;
  • Entrants who have had a career break should demonstrate that they have been in active research for fewer than six years in total since receiving their degree;
  • Where entrants have both an MD and PhD, the date of the most recently awarded degree will be applied;
  • Entries will be judged from the articles published during the year in The Journal of Physiology, by the Editorial Board;
  • The first prize will be $1000 and there are two runner’s up prizes of $500 each;
  • Where more than one Early Investigator has contributed to a winning paper, the prize will be split on the advice of the senior author;
  • Authors will be asked about their eligibility to enter this competition during submission.

If you meet the criteria of the above and wish to be considered for this Prize, at this stage please email jphysiol@physoc.org stating your name, qualifications and citing the volume and page numbers of The Journal in which your article is published. We will then log your interest and be in touch with you in due course.

2016 Results


Calum Wilson and Matthew Lee
Acetylcholine released by endothelial cells facilitates flow-mediated dilatation
Calum Wilson, Matthew D. Lee, John G. McCarron
J Physiol December 15, 2016 594 (24): 7267–7307. doi:10.1113/JP272927

Runners Up

Matthew S. Brook
Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans.
Matthew S. Brook, Daniel J. Wilkinson, William K. Mitchell, Jonathan N. Lund, Bethan E. Phillips, Nathaniel J. Szewczyk, Paul L. Greenhaff, Kenneth Smith, Philip J. Atherton
J Physiol, December 15, 2016 594 (24): 7399–7417. doi:10.1113/JP272857

David G.S. Farmer
Brainstem sources of cardiac vagal tone and respiratory sinus arrhythmia
David G.S. Farmer, Mathias Dutschmann, Julian F.R. Paton, Anthony E. Pickering, Robin M. McAllen
J Physiol, 594: 7249–7265. doi:10.1113/JP273164

Previous Winners



Calum Wilson - Pressure-dependent regulation of Ca2+ signalling in the vascular endothelium, by Calum Wilson, Christopher D. Saunter, John M. Girkin, John G. McCarron, J Physiol December 15, 2015 593 (24) 5231–5253

Runners Up

Esther Krook-Magnuson and Caren Armstrong - In vivo evaluation of the dentate gate theory in epilepsy, by Esther Krook-Magnuson, Caren Armstrong, Anh Bui, Sean Lew, Mikko Oijala, Ivan Soltesz, J Physiol May 15, 593 (10) 2379–2388

David Morales-Alamo - Limitations to oxygen transport and utilization during sprint exercise in humans: evidence for a functional reserve in muscle O2 diffusing capacity by José A. L. Calbet, José Losa-Reyna, Rafael Torres-Peralta, Peter Rasmussen, Jesús Gustavo Ponce-González, A. William Sheel, Jaime de la Calle-Herrero, Amelia Guadalupe-Grau, David Morales-Alamo, Teresa Fuentes, Lorena Rodríguez-García, Christoph Siebenmann, Robert Boushel, Carsten Lundby, J Physiol October 15, 593 (20) 4649–4664



Feng Yi - Direct excitation of parvalbumin-positive interneurons by M1 muscarinic acetylcholine receptors: roles in cellular excitability, inhibitory transmission and cognition, by  Feng Yi, Jackson Ball, Kurt E. Stoll, Vaishali C. Satpute, Samantha M. Mitchell, Jordan L. Pauli, Benjamin B. Holloway, April D. Johnston, Neil M. Nathanson, Karl Deisseroth, David J. Gerber, Susumu Tonegawa and J. Josh Lawrence, J Physiol August 15, 2014 592 (16) 3463-3494

Runners Up

Noah J. Marcus - Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure, by Noah J. Marcus, Rodrigo Del Rio, Evan P. Schultz, Xiao-Hong Xia and Harold D. Schultz, J Physiol January 14, 2014 592 (2) 391-408

Rodrigo Del Rio - Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure, by Noah J. Marcus, Rodrigo Del Rio, Evan P. Schultz, Xiao-Hong Xia and Harold D. Schultz, J Physiol January 14, 2014 592 (2) 391-408




Lasse Gliemann - Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men, by Lasse Gliemann, Jakob Friis Schmidt, Jesper Olesen, Rasmus Sjørup Biensø, Sebastian Louis Peronard, Simon Udsen Grandjean, Stefan Peter Mortensen, Michael Nyberg,  Jens Bangsbo, Henriette Pilegaard and Ylva Hellsten, J Physiol October 14, 2013 591 (20) 5047–5059

Runners Up

Aiste Adomaviciene - Putative pore-loops of TMEM16/anoctamin channels affect channel density in cell membranes, by Aiste Adomaviciene, Keith J. Smith, Hannah Garnett and Paolo Tammaro, J Physiol July 18, 2013 591 (14) 3487–3505

Daniel Wilkinson - Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism, by D. J. Wilkinson, T. Hossain, D. S. Hill, B. E. Phillips, H. Crossland, J. Williams, P. Loughna, T. A. Churchward-Venne, L. Breen, S. M. Phillips, T. Etheridge, J. A. Rathmacher, K. Smith, N. J. Szewczyk and P. J. Atherton, J Physiol May 31, 2013 591 (11) 2911–2923




Rahul Agrawal - Metabolic syndrome' in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition, by Rahul Agrawal and Fernando Gomez-Pinilla, J Physiol May 15, 2012 590 (10) 2485–2499

Runners Up 

Andrés Hernández - Dietary nitrate increases tetanic [Ca2+]i and contractile force in mouse fast-twitch muscle, by Andrés Hernández, Tomas A. Schiffer, Niklas Ivarsson, Arthur J. Cheng, Joseph D. Bruton, Jon O. Lundberg, Eddie Weitzberg andHåkan Westerblad, J Physiol July 27, 2012 590 (15) 3575–3583

Takashi Matsui - Brain glycogen supercompensation following exhaustive exercise, by Takashi Matsui, Taro Ishikawa, Hitoshi Ito, Masahiro Okamoto, Koshiro Inoue, Min-chul Lee, Takahiko Fujikawa, Yukio Ichitani, Kentaro Kawanaka and Hideaki Soya, J Physiol January 27, 2012 590 (3) 607–616

Funder Compliance

Editor's Choice

15 February  - Volume 596 Issue 4

Sodium channel clusters: harmonizing the cardiac conduction orchestra

Rengasayee Veeraraghavan and Przemysław B. Radwa´nski

The role of breakfast in adipose tissue biology

Jun Yoshino

Mixing audio and video in dendrites

Hermann Cuntz

Distribution of cardiac sodium channels in clusters potentiates ephaptic interactions in the intercalated disc

Echrak Hichri, Hugues Abriel and Jan P. Kucera

Molecular adaptations of adipose tissue to 6 weeks of morning fasting vs. daily breakfast consumption in lean and obese adults

Javier T. Gonzalez, Judith D. Richardson, Enhad A. Chowdhury, Francoise Koumanov, Geoffrey D. Holman, Scott Cooper, Dylan Thompson, Kostas Tsintzas and James A. Betts

See all »

Experimental Biology joint virtual issue 2017

Joint Virtual Issue - Experimental Biology 2017

Reflecting the increasingly interdisciplinary nature of life science research, this collection brings together articles published in the journals of the Biochemical Society, the British Pharmacological Society, ASPET and The Physiological Society. Key topics highlighted include neurobiology, gastrointestinal biology, obesity, nutrition, and epigenetics.

All articles are free to read until 31 May. We hope you enjoy our collection!


The repair Schwann cell and its function in regenerating nerves
The Journal of Physiology | K. R. Jessen & R. Mirsky | 10.1113/JP270874

What do we really know about newborn infant pain?
Experimental Physiology | Maria Fitzgerald | 10.1113/EP085134

Retrograde apoptotic signaling by the p75 neurotrophin receptor
Neuronal Signaling | Amrita Pathak & Bruce D. Carter  | 10.1042/NS20160007

Extracellular matrix inflammation in vascular cognitive impairment and dementia
Clinical Science | Gary A. Rosenberg | 10.1042/CS20160604

Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction
Biochemical Journal | Paul Bishop et al | 10.1042/BCJ20160082

Relaxin’ the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders
British Journal of Clinical Pharmacology | Jigna Rajesh Kumar et al | 10.1111/bph.13564

Pharmacological comparison of a nonhuman primate and a rat model of oxaliplatin-induced neuropathic cold hypersensitivity
Pharmacology Research & Perspectives |Yuka Shidahara et al | 10.1002/prp2.216

Gastrointestinal biology

Endogenous and exogenous control of gastrointestinal epithelial function: building on the legacy of Bayliss and Starling
The Journal of Physiology | Kim E. Barrett | 10.1113/JP272227

Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in Sprague–Dawley rats
Experimental Physiology | Maria M. Buckleyet al | 10.1113/EP085917

Gastrointestinal transport of calcium and glucose in lactating ewes
Physiological Reports | Stefanie Klinger et al | 10.14814/phy2.12817

Foxa2 and Hif1ab regulate maturation of intestinal goblet cells by modulating agr2 expression in zebrafish embryos
Biochemical Journal | Yun-Ren Lai et al| 10.1042/BCJ20160392

Age-associated modifications of intestinal permeability and innate immunity in human small intestine
Clinical Science | Angela L. Mani et al|10.1042/CS20150046

Prescription behavior for gastroprotective drugs in new users as a result of communications regarding clopidogrel – proton pump inhibitor interaction
Pharmacology Research & Perspectives | Willemien J. Kruik-Kollöffel et al| 10.1002/prp2.242

Octreotide s.c. depot provides sustained octreotide bioavailability and similar IGF-1 suppression to octreotide LAR in healthy volunteers
British Journal of Clinical Pharmacology | F Tiberg et al| 10.1111/bcp.12698

Hydrogen sulphide protects against NSAID-enteropathy through modulation of bile and the microbiota
British Journal of Pharmocology |RW Blackler et al| 10.1111/bph.12961


Resveratrol supplementation of high-fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring
The Journal of Physiology | Tiande Zou et al | 10.1113/JP273478

Oxidative stress and immunosenescence in spleen of obese mice can be reversed by 2-hydroxyoleic acid
Experimental Physiology | Alina Gheorghe et al | 10.1113/EP086157

Similar degrees of obesity induced by diet or aging cause strikingly different immunologic and metabolic outcomes
Physiological Reports | Kanthi B. Krishna at al | 0.14814/phy2.12708

Energy balalance, body composition, sedentariness and appetite regulation: pathways to obesity
Clinical Sciences | Mark Hopkins et al | 10.1042/CS20160006

New insight on obesity and adipose-derived stem cells using comprehensive metabolomics
Biochemical Journal |Annalaura Mastrangelo at al | 10.1042/BCJ20160241

A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes
Pharmacology Research & Perspectives | Yanyun Chen et al | 10.1002/prp2.278

The effectiveness of pharmaceutical interventions for obesity: weight loss with orlistat and sibutramine in a United Kingdom population-based cohort
British Journal of Clinical Pharmocology | IJ Douglas et al | 10.1111/bcp.12578

Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning
British Journal of Pharmocology | TM Henagan at al | 10.1111/bph.13058


Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers
The Journal of Physiology | Louise M. Burke et al | 10.1113/JP273230

Long term dietary quercetin enrichment as a cardioprotective countermeasure in mdx mice
Experimental Physiology | Christopher Ballmannl et al | 10.1113/EP086091

Undernutrition in pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring
Bioscience Reports |Brittany Beauchamp et al | 10.1042/BSR20150007

Blood triacylglycerols: a lipidomic window on diet and disease
Biochemical Society Transactions | Francis Saunders et al | 10.1042/BST20150235

The potential health effects of dietary phytoestrogens
British Journal of Pharmocology | Ivonne M C M Rietjens at al | 10.1111/bph.13622

Mediterranean diet, dietary polyphenols and low grade inflammation: results from the MOLI-SANI study
British Journal of Clinical Pharmocology |Marialaura Bonaccio at al | 10.1111/bcp.12924


Late gestational intermittent hypoxia induces metabolic and epigenetic changes in male adult offspring mice
The Journal of Physiology |Abdelnaby Khalyfa et al | 10.1113/JP273570

Multigenerational effects of fetal-neonatal iron deficiency on hippocampal BDNF signaling
Physiological Reports | Mariah B. Blegen et al | 10.1002/phy2.96

Epigenetic inheritance of proteostasis and ageing
Essays in Biochemistry | Cheryl Li & Olivia Casanueva | 10.1042/EBC20160025

Epigenetic regulation of skeletal muscle metabolism
Clinical Science | Kirsten F Howlet &, Sean L McGee | 10.1042/CS20160115

A saga of cancer epigenetics: linking epigenetics to alternative splicing
Biochemical Journal| Sathiya Pandi Narayanan et al | 10.1042/BCJ20160147

Downregulation of the Ca2+-activated K+ channel KCa3.1 by histone deacetylase inhibition in human breast cancer cells
Pharmacology Research & Perspectivesl | Susumu Ohya et al | 10.1002/prp2.228

Therapeutic perspectives of epigenetically active nutrients
British Journal of Pharmocology | M Remely et al | 10.1111/bph.12854