Our First 100 Papers


Physiological Reports has now published 100 articles since its launch! The articles cover a large number of topics across all areas of physiology.

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The 100th article published in Physiological Reports is:
Cellular Inhibitor of Apoptosis-2 is a critical regulator of apoptosis in airway epithelial cells treated with asthma-related inflammatory cytokines by Eugene Roscioli, Rhys Hamon, Richard E. Ruffin, Susan Lester, Peter Zalewski

We are delighted by the quality of our first 100 papers and would like to encourage you to take a look. All the published papers can be accessed here >

Editor's Choice Papers
Below are three papers which have been selected as being of particular interest by the Editor-in-Chief and Deputy Editor-in-Chief:

Nephrin missense mutations: induction of endoplasmic reticulum stress and cell surface rescue by reduction in chaperone interactions by Tetyana Drozdova, Joan Papillon and Andrey V. Cybulsky

Exercise-induced muscle glucose uptake in mice with graded, muscle-specific GLUT-4 deletion by Kirsten F. Howlett, Sofianos Andrikopoulos, Joseph Proietto and Mark Hargreaves

Decreased stability of erythroblastic islands in integrin β3-deficient mice by Zhenghui Wang, Olga Vogel, Gisela Kuhn, Max Gassmann and Johannes Vogel

Top Accessed Papers
Below are the articles which have been most accessed since the journal's launch:

Mental stress elicits sustained and reproducible increases in skin sympathetic nerve activity by Matthew D. Muller, Charity L. Sauder and Chester A. Ray

Bright future for physiological research in Physiological Reports by Susan Wray

Adenosine diphosphate reduces infarct size and improves porcine heart function after myocardial infarct by Laurids T. Bune, Jens R. Larsen, Pia Thaning, Nethe E. T. Bune, Peter Rasmussen and Jaya B. Rosenmeier

Enhanced force production in old age is not a far stretch: an investigation of residual force enhancement and muscle architecture by Geoffrey A. Power, Demetri P. Makrakos, Charles L. Rice and Anthony A. Vandervoort

Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF by Karl Swärd, Mardjaneh K. Sadegh, Michiko Mori, Jonas S. Erjefält and Catarina Rippe

Interlimb interactions during bilateral voluntary elbow flexion tasks in chronic hemiparetic stroke by Shuo-Hsiu Chang, Ana Durand-Sanchez, Craig DiTommaso and Sheng Li

Angiotensin II stimulates sympathetic neurotransmission to adipose tissue by Victoria L. King, Victoria L. English, Kalyani Bharadwaj and Lisa A. Cassis

Left ventricular volume regulation in heart failure with preserved ejection fraction by Peter L. M. Kerkhof, J. Yasha Kresh, John K.-J. Li and Guy R. Heyndrickx

Identification and characterization of novel Kirrel isoform during myogenesis by Peter J. Durcan, Nasser Al-Shanti and Claire E. Stewart

Subcutaneous adipose tissue transplantation in diet-induced obese mice attenuates metabolic dysregulation while removal exacerbates it by Michelle T. Foster, Samir Softic, Jody Caldwell, Rohit Kohli, Annette D. deKloet and Randy J. Seeley

Manipulation of arterial stiffness, wave reflections, and retrograde shear rate in the femoral artery using lower limb external compression by Kevin S. Heffernan, Wesley K. Lefferts, Ari G. Kasprowicz, Brendan J. Tarzia, Dick H. Thijssen and Tom D. Brutsaert

Portable acoustic myography – a realistic noninvasive method for assessment of muscle activity and coordination in human subjects in most home and sports settings by Adrian P. Harrison, Bente Danneskiold-Samsøe and Else M. Bartels

Insulin and GLP-1 infusions demonstrate the onset of adipose-specific insulin resistance in a large fasting mammal: potential glucogenic role for GLP-1 by Jose A. Viscarra, Ruben Rodriguez, Jose Pablo Vazquez-Medina, Andrew Lee, Michael S. Tift, Stephen K. Tavoni, Daniel E. Crocker and Rudy M. Ortiz

Adenosine A1 receptor signaling inhibits BK channels through a PKCα-dependent mechanism in mouse aortic smooth muscle by S. S. Kunduri, G. M. Dick, M. A. Nayeem and S. J. Mustafa

Below you can see the locations of the authors of the first 100 accepted articles

A unique collaboration between
the American Physiological Society
and The Physiological Society

Physiological Reports has published its latest podcast!

Physiological Reports - Author Podcast 12, Dr. Erika I. Boesen

Please join Deputy Editor,  Tom Kleyman and Erika Boesen  as they discuss a recently published manuscript by Dr. Boesen  entitled "Lack of an apparent role for endothelin-1 in the prolonged reduction in renal perfusion following severe unilateral ischemia-reperfusion injury in the mouse”.


Previous Podcasts and Video Abstracts

Video Abstract 1 

Author Podcast 11 Dr. Mathew Piasecki

Author Podcast 10 Dr. Rachel Drew

Author Podcast 9 Dr. Maureen Gannon

Author Podcast 8 Dr. Matthew Muller

Author Podcast 7 Dr. Lori Bogren

Author Podcast 6 Dr. Jun Sun

Author Podcast 5 Scott Stephens and Mahendra Damarla

Author Podcast 4 Judy Blaine

Author Podcast 3 Don Kohan

Author Podcast 2 Jonathan Street

Author Podcast 1 Chet Ray

Editors’ Choice

Differences in oxidative metabolism modulation induced by ischemia/reperfusion between trained and untrained individuals assessed by NIRS

Authors: Rogério N. Soares, Kaitlin M. McLay, Mitchell A. George, Juan M. Murias

Local production of neurostradiol affects gonadotropinreleasing hormone (GnRH) secretion at midgestation in Lagostomus maximus(Rodentia, Caviomorpha)

Authors: Santiago E. Charif, Pablo I. F. Inserra, Alejandro R. Schmidt, Noelia P. Di Giorgio, Santiago A. Cortasa, Candela R. Gonzalez, Victoria Lux‐Lantos, Julia Halperin, Alfredo Daniel Vitullo, Verónica B. Dorfman

Expression of genes involved in carbohydratelipid metabolism in muscle and fat tissues in the initial stage of adultage obesity in fed and fasted mice

Authors: Nadezhda M. Bazhan, Alexandr V. Baklanov, Julia V. Piskunova, Antonina J. Kazantseva, Elena N. Makarova

Exposure to electronic cigarette vapors affects pulmonary and systemic expression of circadian molecular clock genes

Authors: Ariane Lechasseur, Éric Jubinville, Joanie Routhier, Jean‐Christophe Bérubé, Mélanie Hamel‐Auger, Maude Talbot, Jennifer Lamothe, Sophie Aubin, Marie‐Ève Paré, Marie‐Josée Beaulieu, et al

 

See all »

Experimental Biology joint virtual issue 2017

Joint Virtual Issue - Experimental Biology 2017

Reflecting the increasingly interdisciplinary nature of life science research, this collection brings together articles published in the journals of the Biochemical Society, the British Pharmacological Society, ASPET and The Physiological Society. Key topics highlighted include neurobiology, gastrointestinal biology, obesity, nutrition, and epigenetics.

All articles are free to read until 31 May. We hope you enjoy our collection!


Neurobiology

The repair Schwann cell and its function in regenerating nerves
The Journal of Physiology | K. R. Jessen & R. Mirsky | 10.1113/JP270874

What do we really know about newborn infant pain?
Experimental Physiology | Maria Fitzgerald | 10.1113/EP085134

Retrograde apoptotic signaling by the p75 neurotrophin receptor
Neuronal Signaling | Amrita Pathak & Bruce D. Carter  | 10.1042/NS20160007

Extracellular matrix inflammation in vascular cognitive impairment and dementia
Clinical Science | Gary A. Rosenberg | 10.1042/CS20160604

Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction
Biochemical Journal | Paul Bishop et al | 10.1042/BCJ20160082

Relaxin’ the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders
British Journal of Clinical Pharmacology | Jigna Rajesh Kumar et al | 10.1111/bph.13564

Pharmacological comparison of a nonhuman primate and a rat model of oxaliplatin-induced neuropathic cold hypersensitivity
Pharmacology Research & Perspectives |Yuka Shidahara et al | 10.1002/prp2.216


Gastrointestinal biology

Endogenous and exogenous control of gastrointestinal epithelial function: building on the legacy of Bayliss and Starling
The Journal of Physiology | Kim E. Barrett | 10.1113/JP272227

Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in Sprague–Dawley rats
Experimental Physiology | Maria M. Buckleyet al | 10.1113/EP085917

Gastrointestinal transport of calcium and glucose in lactating ewes
Physiological Reports | Stefanie Klinger et al | 10.14814/phy2.12817

Foxa2 and Hif1ab regulate maturation of intestinal goblet cells by modulating agr2 expression in zebrafish embryos
Biochemical Journal | Yun-Ren Lai et al| 10.1042/BCJ20160392

Age-associated modifications of intestinal permeability and innate immunity in human small intestine
Clinical Science | Angela L. Mani et al|10.1042/CS20150046

Prescription behavior for gastroprotective drugs in new users as a result of communications regarding clopidogrel – proton pump inhibitor interaction
Pharmacology Research & Perspectives | Willemien J. Kruik-Kollöffel et al| 10.1002/prp2.242

Octreotide s.c. depot provides sustained octreotide bioavailability and similar IGF-1 suppression to octreotide LAR in healthy volunteers
British Journal of Clinical Pharmacology | F Tiberg et al| 10.1111/bcp.12698

Hydrogen sulphide protects against NSAID-enteropathy through modulation of bile and the microbiota
British Journal of Pharmocology |RW Blackler et al| 10.1111/bph.12961


Obesity

Resveratrol supplementation of high-fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring
The Journal of Physiology | Tiande Zou et al | 10.1113/JP273478

Oxidative stress and immunosenescence in spleen of obese mice can be reversed by 2-hydroxyoleic acid
Experimental Physiology | Alina Gheorghe et al | 10.1113/EP086157

Similar degrees of obesity induced by diet or aging cause strikingly different immunologic and metabolic outcomes
Physiological Reports | Kanthi B. Krishna at al | 0.14814/phy2.12708

Energy balalance, body composition, sedentariness and appetite regulation: pathways to obesity
Clinical Sciences | Mark Hopkins et al | 10.1042/CS20160006

New insight on obesity and adipose-derived stem cells using comprehensive metabolomics
Biochemical Journal |Annalaura Mastrangelo at al | 10.1042/BCJ20160241

A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes
Pharmacology Research & Perspectives | Yanyun Chen et al | 10.1002/prp2.278

The effectiveness of pharmaceutical interventions for obesity: weight loss with orlistat and sibutramine in a United Kingdom population-based cohort
British Journal of Clinical Pharmocology | IJ Douglas et al | 10.1111/bcp.12578

Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning
British Journal of Pharmocology | TM Henagan at al | 10.1111/bph.13058


Nutrition

Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers
The Journal of Physiology | Louise M. Burke et al | 10.1113/JP273230

Long term dietary quercetin enrichment as a cardioprotective countermeasure in mdx mice
Experimental Physiology | Christopher Ballmannl et al | 10.1113/EP086091

Undernutrition in pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring
Bioscience Reports |Brittany Beauchamp et al | 10.1042/BSR20150007

Blood triacylglycerols: a lipidomic window on diet and disease
Biochemical Society Transactions | Francis Saunders et al | 10.1042/BST20150235

The potential health effects of dietary phytoestrogens
British Journal of Pharmocology | Ivonne M C M Rietjens at al | 10.1111/bph.13622

Mediterranean diet, dietary polyphenols and low grade inflammation: results from the MOLI-SANI study
British Journal of Clinical Pharmocology |Marialaura Bonaccio at al | 10.1111/bcp.12924


Epigenetics

Late gestational intermittent hypoxia induces metabolic and epigenetic changes in male adult offspring mice
The Journal of Physiology |Abdelnaby Khalyfa et al | 10.1113/JP273570

Multigenerational effects of fetal-neonatal iron deficiency on hippocampal BDNF signaling
Physiological Reports | Mariah B. Blegen et al | 10.1002/phy2.96

Epigenetic inheritance of proteostasis and ageing
Essays in Biochemistry | Cheryl Li & Olivia Casanueva | 10.1042/EBC20160025

Epigenetic regulation of skeletal muscle metabolism
Clinical Science | Kirsten F Howlet &, Sean L McGee | 10.1042/CS20160115

A saga of cancer epigenetics: linking epigenetics to alternative splicing
Biochemical Journal| Sathiya Pandi Narayanan et al | 10.1042/BCJ20160147

Downregulation of the Ca2+-activated K+ channel KCa3.1 by histone deacetylase inhibition in human breast cancer cells
Pharmacology Research & Perspectivesl | Susumu Ohya et al | 10.1002/prp2.228

Therapeutic perspectives of epigenetically active nutrients
British Journal of Pharmocology | M Remely et al | 10.1111/bph.12854