F1000Prime recommendations


F1000Prime is an in-depth directory of the top articles in biology and medicine, as recommended by a Faculty of over 5,000 expert scientists and clinical researchers, assisted by 5,000 associates. Articles are rated and expert commentaries explain their importance.

The Physiological Society offers FREE ACCESS to a selection of recommendations each month.  These free links are denoted below. The recommendations help to put the articles in context and provide opinion and perspective from leading scientists working in the field.

The F1000Prime recommendations

F1000 Prime link

   F1000Prime recommended articles


*FREE Until 30 May 2017*

HCN channels segregate stimulation-evoked movement responses in neocortex and allow for coordinated forelimb movements in rodents
Jeffery A. Boychuk, Jordan S. Farrell, Laura A. Palmer, Anna C. Singleton, Quentin J. Pittman, G. Campbell Teskey
J Physiol, doi:10.1113/JP273068

Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers
Louise M. Burke, Megan L. Ross, Laura A. Garvican-Lewis, Marijke Welvaert, Ida A. Heikura, Sara G. Forbes, Joanne G. Mirtschin, Louise E. Cato, Nicki Strobel, Avish P. Sharma, John A. Hawley
J Physiol, doi:10.1113/JP273230

Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice
Anton N. Shuvaev, Nobutake Hosoi, Yamato Sato, Dai Yanagihara, Hirokazu Hirai
J Physiol, 595: 141–164. doi:10.1113/JP272950

Cellular and circuit mechanisms underlying spinocerebellar ataxias
Pratap Meera, Stefan M. Pulst, Thomas S. Otis
J Physiol, 594: 4653–4660. doi:10.1113/JP271897

Are Type 1 metabotropic glutamate receptors a viable therapeutic target for the treatment of cerebellar ataxia?
Emmet M. Power, Natalya A. English, Ruth M. Empson
J Physiol, 594: 4643–4652. doi:10.1113/JP271153

Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 proteins in human skeletal muscle
Jonas T. Treebak, Christian Pehmøller, Jonas M. Kristensen, Rasmus Kjøbsted, Jesper B. Birk, Peter Schjerling, Erik A. Richter, Laurie J. Goodyear, Jørgen F. P. Wojtaszewski
J Physiol, 592: 351–375. doi:10.1113/jphysiol.2013.266338

Obesity-induced lymphatic dysfunction is reversible with weight loss
Nitti, M. D., Hespe, G. E., Kataru, R. P., García Nores, G. D., Savetsky, I. L., Torrisi, J. S., Gardenier, J. C., Dannenberg, A. J. and Mehrara, B. J.
J Physiol, 594: 7073–7087. doi:10.1113/JP273061

Voltage-sensitive conductances increase the sensitivity of rod photoresponses following pigment bleaching
Pahlberg, J., Frederiksen, R., Pollock, G. E., Miyagishima, K. J., Sampath, A. P. and Cornwall, M. C.

Three brainstem areas involved in respiratory rhythm generation in bullfrogs
Mufaddal I. Baghdadwala, Maryana Duchcherer, Jenny Paramonov, Richard J. A. Wilson
J Physiol, 593: 2941–2954. doi:10.1113/JP270380

μ opioid receptor activation hyperpolarizes respiratory-controlling Kölliker-Fuse neurons and suppresses post-inspiratory drive
Erica S. Levitt, Ana P. Abdala, Julian F. R. Paton, John M. Bissonnette, John T. Williams
J Physiol, 593: 4453–4469. doi:10.1113/JP270822

State-dependent control of breathing by the retrotrapezoid nucleus
Peter G.R. Burke, Roy Kanbar, Tyler M. Basting, Walter M. Hodges, Kenneth E. Viar, Ruth L. Stornetta, Patrice G. Guyenet
J Physiol, 593: 2909–2926. doi:10.1113/JP270053

The impacts of age and frailty on heart rate and sinoatrial node function
Motahareh Moghtadaei, Hailey J. Jansen, Martin Mackasey, Sara A. Rafferty, Oleg Bogachev, John L. Sapp, Susan E. Howlett, Robert A. Rose
J Physiol, 593: 2909–2926. doi:10.1113/JP270053


Accumulation of K(+) in the synaptic cleft modulates activity by influencing both vestibular hair cell and calyx afferent in the turtle.
Donatella Contini, Steven D. Price, Jonathan J. Art
J Physiol, 595: 777–803. doi:10.1113/JP273060

Effect of aerobic fitness on capillary blood volume and diffusing membrane capacity responses to exercise
Vincent Tedjasaputra, Melissa M. Bouwsema, Michael K. Stickland
J Physiol, 594: 4359–4370. doi:10.1113/JP272037

The relative contributions of store-operated and voltage-gated Ca(2+) channels to the control of Ca(2+) oscillations in airway smooth muscle
Sebastian Boie, Jun Chen, Michael J. Sanderson, James Sneyd
J Physiol. doi:10.1113/JP272996

Post-tetanic potentiation is caused by two signalling mechanisms affecting quantal size and quantal content
Lei Xue, Ling-Gang Wu
J Physiol, 588: 4987–4994. doi:10.1113/jphysiol.2010.196964

Contribution of neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts
Sudhish Mishra, Vitaliy Reznikov, Victor A. Maltsev, Nidas A. Undrovinas, Hani N. Sabbah, Albertas Undrovinas
J Physiol, 593: 1409–1427. doi:10.1113/jphysiol.2014.278259

Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs
Christina Nassenstein, Thomas E. Taylor-Clark, Allen C. Myers, Fei Ru, Rajender Nandigama, Weston Bettner, Bradley J. Undem
J Physiol,  588: 4769–4783. doi:10.1113/jphysiol.2010.195339

Burst activity and ultrafast activation kinetics of CaV1.3 Ca²⁺ channels support presynaptic activity in adult gerbil hair cell ribbon synapses
Valeria Zampini, Stuart L. Johnson, Christoph Franz, Marlies Knipper, Matthew C. Holley, Jacopo Magistretti, Sergio Masetto, Walter Marcotti
J Physiol, 591: 3811–3820. doi:10.1113/jphysiol.2013.251272

Daily variation in the electrophysiological activity of mouse medial habenula neurones
Kanwal Sakhi, Mino D. C. Belle, Nicole Gossan, Philippe Delagrange, Hugh D. Piggins
J Physiol, 592: 587–603. doi:10.1113/jphysiol.2013.263319

Magnesium sulphate and cardiovascular and cerebrovascular adaptations to asphyxia in preterm fetal sheep
Robert Galinsky, Joanne O. Davidson, Paul P. Drury, Guido Wassink, Christopher A. Lear, Lotte G. van den Heuij, Alistair J. Gunn, Laura Bennet
J Physiol, 594: 1281–1293. doi:10.1113/JP270614

White paper: Uncertainty and variability in computational and mathematical models of cardiac physiology
Gary R. Mirams, Pras Pathmanathan, Richard A. Gray, Peter Challenor, Richard H. Clayton
J Physiol, 594: 6833–6847. doi:10.1113/JP271671

Thyroid hormone activation by type-2 deiodinase mediates exercise-induced PGC-1a expression in skeletal muscle
Barbara M. L. C. Bocco, Ruy A. N. Louzada, Diego H. S. Silvestre, Maria C. S. Santos, Elena Anne‐Palmer, Igor F. Rangel, Sherine Abdalla, Andrea C. Ferreira, Miriam O. Ribeiro, Balázs Gereben, Denise P. Carvalho, Antonio C. Bianco, João P. Werneck‐de‐Castro
J Physiol, 594: 5255–5269. doi:10.1113/JP272440

Individual variability of cerebral autoregulation, posterior cerebral circulation and white matter hyperintensity
Jie Liu, Benjamin Y. Tseng, Muhammad Ayaz Khan, Takashi Tarumi, Candace Hill, Niki Mirshams, Timea M. Hodics, Linda S. Hynan, Rong Zhang
J Physiol, 594: 3141–3155. doi:10.1113/JP271068

Optogenetic and pharmacological evidence that somatostatin-GABA neurons are important regulators of parasympathetic outflow to the stomach
Amanda E. Lewin, Stefano Vicini, Janell Richardson, Kenneth L. Dretchen, Richard A. Gillis, Niaz Sahibzada
J Physiol, 594: 2661–2679. doi:10.1113/JP272069

Is ageing 'highly individualistic'?
David A. Jones, Jamie S. McPhee, Hans Degens
J Physiol, 593: 3219. doi:10.1113/JP270420

Effect of midbrain stimulations on thermoregulatory vasomotor responses in rats
Yi‐Hong Zhang, Takayoshi Hosono, Motoko Yanase‐Fujiwara, Xiao‐Ming Chen, Kazuyuki Kanosue
J Physiol, 503: 177–186. doi:10.1111/j.1469-7793.1997.177bi.x

Genetic manipulation of cardiac ageing
Leah Cannon, Rolf Bodmer
J Physiol, 594: 2075–2083. doi:10.1113/JP270563

Proton detection and breathing regulation by the retrotrapezoid nucleus
Patrice G. Guyenet, Douglas A. Bayliss, Ruth L. Stornetta, Marie‐Gabrielle Ludwig, Natasha N. Kumar, Yingtang Shi, Peter G. R. Burke, Roy Kanbar, Tyler M. Basting, Benjamin B. Holloway, Ian C. Wenker
J Physiol, 594: 1529–1551. doi:10.1113/JP271480

Rad and Rem are non-canonical G-proteins with respect to the regulatory role of guanine nucleotide binding in Ca(V)1.2 channel regulation
Donald D. Chang, Henry M. Colecraft
J Physiol, 593: 5075–5090. doi:10.1113/JP270889

Carotid body chemoreflex: a driver of autonomic abnormalities in sleep apnoea
Nanduri R. Prabhakar
Exp Physiol, 101: 975–985. doi:10.1113/EP085624

A proportional assist ventilator to unload respiratory muscles experimentally during exercise in humans
Paolo B. Dominelli, William R. Henderson, A. William Sheel
Exp Physiol, 101: 754–767. doi:10.1113/EP085735


Hypoxic pulmonary vasoconstriction, carotid body function and erythropoietin production in adult rats perinatally exposed to hyperoxia
Jesus Prieto‐Lloret, Maria Ramirez, Elena Olea, Javier Moral‐Sanz, Angel Cogolludo, Javier Castañeda, Sara Yubero, Teresa Agapito, Angela Gomez‐Niño, Asuncion Rocher, et al
 J Physiol, 593: 2459–2477. doi:10.1113/JP270274

Pressure-dependent regulation of Ca2+ signalling in the vascular endothelium
Calum Wilson, Christopher D. Saunter, John M. Girkin, John G. McCarron
J Physiol, 593: 5231–5253. doi:10.1113/JP271157

Integrative regulation of human brain blood flow
Christopher K. Willie, Yu-Chieh Tzeng, Joseph A. Fisher, Philip N. Ainslie
J Physiol, 592: 841–859. doi:10.1113/jphysiol.2013.268953

Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice.
Yasumatsu K, Manabe T, Yoshida R, Iwatsuki K, Uneyama H, Takahashi I, Ninomiya Y
 J Physiol, 593: 1021–1034. doi:10.1113/jphysiol.2014.284703

Carotid body over activity induces respiratory neurone channelopathy contributing to neurogenic hypertension.
Moraes DJ, Machado BH, Paton JF.
 J Physiol, 593: 3055–3063. doi:10.1113/JP270423

Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts.
Lin X, O'Malley H, Chen C, Auerbach D, Foster M, Shekhar A, Zhang M, Coetzee W, Jalife J, Fishman GI, Isom L, Delmar M.
 J Physiol, 593: 1389–1407. doi:10.1113/jphysiol.2014.277699

Differential effects of GLP-1 on Microvascular Recruitment and Glucose Metabolism in Short - and Long term Insulin Resistance.
Sjøberg KA, Rattigan S, Jeppesen JF, Lundsgaard AM, Holst JJ, Kiens B
J Physiol, 593: 2185–2198. doi:10.1113/JP270129


Exposure to a high fat diet during the perinatal period alters vagal motoneurone excitability, even in the absence of obesity.
Bhagat R, Fortna SR, Browning KN
 J Physiol, 593: 285–303. doi:10.1113/jphysiol.2014.282806

Microdomain [Ca²⁺] near ryanodine receptors as reported by L-type Ca²⁺ and Na+/Ca²⁺ exchange currents.
Acsai K, Antoons G, Livshitz L, Rudy Y, Sipido KR
J Physiol, 589: 2569–2583. doi:10.1113/jphysiol.2010.202663

Intrinsic vascular dopamine - a key modulator of hypoxia-induced vasodilatation in splanchnic vessels.
Pfeil U, Kuncova J, Brüggmann D, Paddenberg R, Rafiq A, Henrich M, Weigand MA, Schlüter KD, Mewe M, Middendorff R, Slavikova J, Kummer W
 J Physiol, 592: 1745–1756. doi:10.1113/jphysiol.2013.262626

CrossTalk opposing view: Which technique for controlling resistant hypertension? Carotid chemoreceptor denervation/modulation.
Ratcliffe LE, Pijacka W, McBryde FD, Abdala AP, Moraes DJ, Sobotka PA, Hart EC, Narkiewicz K, Nightingale AK, Paton JF
 J Physiol, 592: 3941–3944. doi:10.1113/jphysiol.2013.268227

Diabetic kidney disease: from Physiology to Therapeutics
Mora-Fernández C, Domínguez-Pimentel V, de Fuentes MM, Górriz JL, Martínez-Castelao A, Navarro-González JF
J Physiol, 592: 3997–4012. doi:10.1113/jphysiol.2014.272328

Transcranial Cerebellar Direct Current Stimulation and Transcutaneous Spinal Cord Direct Current Stimulation as Innovative Tools for Neuroscientists.
Priori A, Ciocca M, Parazzini M, Vergari M, Ferrucci R
 J Physiol, 592: 3345–3369. doi:10.1113/jphysiol.2013.270280

Consequences of peripheral chemoreflex inhibition with low-dose dopamine in humans
Piotr Niewinski, Stanislaw Tubek, Waldemar Banasiak, Julian F. R. Paton, and Piotr Ponikowski
 J Physiology, 592: 1295–1308. doi:10.1113/jphysiol.2013.266858

Resting pulmonary haemodynamics and shunting: a comparison of sea-level inhabitants to high altitude Sherpas
Glen E. Foster, Philip N. Ainslie, Mike Stembridge, Trevor A. Day, Akke Bakker, Samuel J. E. Lucas, Nia C. S. Lewis, David B. MacLeod, and Andrew T. Lovering
J Physiol, 592: 1397–1409. doi:10.1113/jphysiol.2013.26659

Age-related changes in afferent pathways and urothelial function in the male mouse bladder
Donna M. Daly, Linda Nocchi, Marina Liaskos, Neil G. McKay, Christopher Chapple, and David Grundy
J Physiol, 592: 537–549. doi:10.1113/jphysiol.2013.262634

Placement of implantable cardioverter-defibrillators in paediatric and congenital heart defect patients: a pipeline for model generation and simulation prediction of optimal configurations
Lukas J. Rantner, Fijoy Vadakkumpadan, Philip J. Spevak, Jane E. Crosson, and Natalia A. Trayanova
J Physiol, 591: 4321–4334. doi:10.1113/jphysiol.2013.255109

Reflex control of inflammation by sympathetic nerves, not the vagus
D. Martelli, S. T. Yao, M. J. McKinley, and R. M. McAllen
J Physiol, 592: 1677–1686. doi:10.1113/jphysiol.2013.268573

Neurotensin inhibition of GABAergic transmission via mGluR-induced endocannabinoid signalling in rat periaqueductal grey
D. A. Mitchell, H. Kawahara, and C. W. Vaughan
J Physiol, 587: 2511–2520. doi:10.1113/jphysiol.2008.16742

The role of myogenic mechanisms in human cerebrovascular regulation
Can Ozan Tan, J. W. Hamner, and J. Andrew Taylor
J Physiol, 591: 5095–5105. doi:10.1113/jphysiol.2013.259747

The intent to exercise influences the cerebral O2/carbohydrate uptake ratio in humans
Mads K Dalsgaard, Kojiro Ide, Yan Cai, Bjørn Quistorff, and Niels H Secher
J Physiol, 540: 681–689. doi:10.1113/jphysiol.2001.013062

Integrative physiological and computational approaches to understand autonomic control of cerebral autoregulation
Can Ozan Tan and J. Andrew Taylor
Exp Physiol, 99: 3–15. doi:10.1113/expphysiol.2013.072355

Blood flow in internal carotid and vertebral arteries during orthostatic stress
Kohei Sato, James P. Fisher, Thomas Seifert, Morten Overgaard, Niels H. Secher, and Shigehiko Ogoh
Exp Physiol,  97: 1272–1280. doi:10.1113/expphysiol.2012.064774

Normal mucus formation requires cAMP-dependent HCO3− secretion and Ca2 -mediated mucin exocytosis
Ning Yang, Mary Abigail S. Garcia, and Paul M. Quinton
J Physiol, 591: 4581–4593. doi:10.1113/jphysiol.2013.257436

Integrative regulation of human brain blood flow
Christopher K. Willie, Yu-Chieh Tzeng, Joseph A. Fisher, and Philip N. Ainslie
J Physiol, 592: 841–859. doi:10.1113/jphysiol.2013.268953

Assessment of dynamic cerebral autoregulation and cerebrovascular CO2 reactivity in aging by measurements of cerebral blood flow and cortical oxygenation
Madelijn H. Oudegeest-Sander, Arenda H.E.A. van Beek, Karin Abbink, Marcel G.M. Olde Rikkert, Maria T.E. Hopman and Jurgen A.H.R. Claassen
Exp Physiol, 99: 586–598. doi:10.1113/expphysiol.2013.076455


Low voltage-activated calcium channels gate transmitter release at the dorsal root ganglion sandwich synapse
Gabriela M. Rozanski, Arup R. Nath, Michael E. Adams, and Elise F. Stanley
J Physiol, 591: 5575–5583. doi:10.1113/jphysiol.2013.260281

Cellular properties and chemosensory responses of the human carotid body
Patricia Ortega-Saenz, Ricardo Pardal, Konstantin Levitsky, Javier Villadiego, Ana B Muñoz-Manchado, Rocio Duran, Victoria Bonilla-Henao, Ignacio Arias-Mayenco, Veronica Sobrino, Antonio Ordoñez, Maria Oliver, Juan Jose Toledo-Aral and Jose Lopez-Barneo
J Physiol, 591: 6157–6173. doi:10.1113/jphysiol.2013.263657

Cardiorespiratory coupling of sympathetic outflow in humans: a comparison of respiratory and cardiac modulation of sympathetic nerve activity to skin and muscle
Rania Fatouleh and Vaughan G. Macefield
Exp Physiol, 98: 1327–1336. doi:10.1113/expphysiol.2013.072421

Is this my finger? Proprioceptive illusions of body ownership and representation
Martin E Héroux, Lee D Walsh, Annie A Butler, and Simon C Gandevia
J Physiol, 591: 5661–5670. doi:10.1113/jphysiol.2013.261461

Etomidate and propofol inhibit the neurotransmitter release machinery at different sites
Bruce E. Herring, Kyle McMillan, Carolyn M. Pike, Jeremy Marks, Aaron P. Fox, and Zheng Xie
J Physiol, 589: 1103–1115. doi:10.1113/jphysiol.2010.200964

Effect of inspiratory muscle fatigue on exercise performance taking into account the fatigue-induced excess respiratory drive
Thomas U. Wüthrich, Dominic A. Notter, and Christina M. Spengler
Exp Physiol, 98: 1705–1717. doi:10.1113/expphysiol.2013.073635

The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β
Nathan A. Bracey, Paul L. Beck, Daniel A. Muruve, Simon A. Hirota, Jiqing Guo, Habib Jabagi, James R. Wright, Jr, Justin A. MacDonald, James P. Lees-Miller, Daniel Roach, Lisa M. Semeniuk, and Henry J. Duff
Exp Physiol, 98: 462–472. doi:10.1113/expphysiol.2012.068338

Muscle metaboreflex and autonomic regulation of heart rate in humans
James P. Fisher, Ahmed M. Adlan, Alena Shantsila, J. Frederik Secher, Henrik Sørensen, and Niels H. Secher
J Physiol, 591: 3777–3788. doi:10.1113/jphysiol.2013.254722

Heterogeneous responses of nucleus incertus neurons to corticotrophin-releasing factor and coherent activity with hippocampal theta rhythm in the rat
Sherie Ma, Anna Blasiak, Francisco E. Olucha-Bordonau, Anthony J. M. Verberne, and Andrew L. Gundlach
J Physiol, 591: 3981–4001. doi:10.1113/jphysiol.2013.254300

The essential role of peripheral respiratory chemoreceptor inputs in maintaining breathing revealed when CO2 stimulation of central chemoreceptors is diminished
Marie-Noëlle Fiamma, Edward T. O'Connor, Arijit Roy, Ines Zuna, and Richard J. A. Wilson
J Physiol, 591: 1507–1521. doi:10.1113/jphysiol.2012.247304

Testosterone restores respiratory long term facilitation in old male rats by an aromatase-dependent mechanism
N. R. Nelson, I. M. Bird, and M. Behan
J Physiol, 589: 409–421. doi:10.1113/jphysiol.2010.198200

Ageing and gonadectomy have similar effects on hypoglossal long-term facilitation in male Fischer rats
A. G Zabka, G. S Mitchell, and M Behan
J Physiol, 563: 557–568. doi:10.1113/jphysiol.2004.077511

Spinal 5-HT7 receptor activation induces long-lasting phrenic motor facilitation
M. S. Hoffman and G. S. Mitchell
J Physiol, 589: 1397–1407. doi:10.1113/jphysiol.2010.201657

The role of α-adrenergic receptors in mediating beat-by-beat sympathetic vascular transduction in the forearm of resting man
Seth T. Fairfax, Seth W. Holwerda, Daniel P. Credeur, Mozow Y. Zuidema, John H. Medley, Peter C. Dyke II, D. Walter Wray, Michael J. Davis, and Paul J. Fadel
J Physiol, 591: 3637–3649. doi:10.1113/jphysiol.2013.250894

Episodic hypoxia evokes long-term facilitation of genioglossus muscle activity in neonatal rats
Leanne C. McKay, Wiktor A. Janczewski, and Jack L. Feldman
J Physiol,  557: 13–18. doi:10.1113/jphysiol.2004.064006

Dopaminergic Modulation of Axonal Potassium Channel and Action Potential Waveform in Pyramidal Neurons of Prefrontal Cortex
Jing Yang, Mingyu Ye, Cuiping Tian, Mingpo Yang, Yonghong Wang, and Yousheng Shu
J Physiol, 591: 3233–3251. doi:10.1113/jphysiol.2013.251058

Pulmonary hypertension and the right ventricle in hypoxia
Robert Naeije and Chantal Dedobbeleer
Exp Physiol, 98: 1247–1256. doi:10.1113/expphysiol.2012.069112

Sarcolemmal localisation of Na /H exchange and Na –HCO3− co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes
Carolina D. Garciarena, Yu-ling Ma, Pawel Swietach, Laurence Huc, and Richard D. Vaughan-Jones
J Physiol, 591: 2287–2306. doi:10.1113/jphysiol.2012.249664

A critical re-evaluation of the specificity of action of perivagal capsaicin
K. N. Browning, T. Babic, G. M. Holmes, E. Swartz, and R. A. Travagli
J Physiol, 591: 1563–1580. doi:10.1113/jphysiol.2012.246827

Neonatal stress augments the hypoxic chemoreflex of adult male rats by increasing AMPA-receptor mediated modulation
Roumiana Gulemetova, Guy Drolet and Richard Kinkead
Exp Physiol, 98: 1312–1324. doi:10.1113/expphysiol.2013.072090

Physiology is rocking the foundations of evolutionary biology
Denis Noble
Exp Physiol, 98: 1235–1243. doi:10.1113/expphysiol.2012.071134

Cardiac-locked bursts of muscle sympathetic nerve activity are absent in familial dysautonomia
Vaughan G. Macefield, Lucy Norcliffe-Kaufmann, Felicia B. Axelrod, and Horacio Kaufmann
J Physiol, 591: 689–700. doi:10.1113/jphysiol.2012.246264

Imaging and characterization of stretch-induced ATP release from alveolar A549 cells
Ryszard Grygorczyk, Kishio Furuya, and Masahiro Sokabe
J Physiol, 591: 1195–1215. doi:10.1113/jphysiol.2012.244145

Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2 channels in mouse sinoatrial node
Carl J. Christel, Natalia Cardona, Pietro Mesirca, Stefan Herrmann, Franz Hofmann, Joerg Striessnig, Andreas Ludwig, Matteo E. Mangoni, and Amy Lee
J Physiol, 590: 6327–6341. doi:10.1113/jphysiol.2012.239954

Renal sympathoinhibitory and regional vasodilator responses to cholecystokinin are altered in obesity-related hypertension
Jackie M. Y. How, Talia J. Pumpa, and Daniela M. Sartor
Exp Physiol, 98: 655–664. doi:10.1113/expphysiol.2012.070151

Tracheal occlusion conditioning causes stress, anxiety and neural state changes in conscious rats
K. M. Pate and P. W. Davenport
Exp Physiol, 98: 819–829. doi:10.1113/expphysiol.2012.068924

The regulation of interleukin-6 implicates skeletal muscle as an integrative stress sensor and endocrine organ
Steven S. Welc and Thomas L. Clanton
Exp Physiol, 98: 359–371. doi:10.1113/expphysiol.2012.068189

Orai3 – the ‘exceptional' Orai?
Trevor J. Shuttleworth
J Physiol,  590: 241–257. doi:10.1113/jphysiol.2011.220574

Motor-cortical oscillations in early stages of Parkinson's disease
B. Pollok, V. Krause, W. Martsch, C. Wach, A. Schnitzler, and M. Südmeyer
J Physiol, 590: 3203–3212. doi:10.1113/jphysiol.2012.231316

Adverse cardiac remodelling in spontaneously hypertensive rats: acceleration by high aerobic exercise intensity
Rui Manuel da Costa Rebelo, Rolf Schreckenberg, and Klaus-Dieter Schlüter
J Physiol, 590: 5389–5400. doi:10.1113/jphysiol.2012.241141

Descending control of the respiratory neuronal network by the midbrain periaqueductal grey in the rat in vivo
Hari H. Subramanian
J Physiol, 591: 109–122. doi:10.1113/jphysiol.2012.245217

Lifelong physical activity preserves functional sympatholysis and purinergic signalling in the ageing human leg
S. P. Mortensen, M. Nyberg, K. Winding, and B. Saltin
J Physiol,  590: 6227–6236. doi:10.1113/jphysiol.2012.240093

Exploiting mathematical models to illuminate electrophysiological variability between individuals
Amrita X. Sarkar, David J. Christini, and Eric A. Sobie
J Physiol, 590: 2555–2567. doi:10.1113/jphysiol.2011.223313

Individual differences in the cardiovascular responses to tonic muscle pain: parallel increases or decreases in muscle sympathetic nerve activity, blood pressure and heart rate
Azharuddin Fazalbhoy, Ingvars Birznieks, and Vaughan G. Macefield
Exp Physiol,  97: 1084–1092. doi:10.1113/expphysiol.2012.066191

Physical activity opposes coronary vascular dysfunction induced during high fat feeding in mice
Yoonjung Park, Frank W. Booth, Sewon Lee, Mathew J. Laye, and Cuihua Zhang
J Physiol, 590: 4255–4268. doi:10.1113/jphysiol.2012.234856


The pulmonary vascular response to combined activation of the muscle metaboreflex and mechanoreflex
Michael J White, Christos K Lykidis, and George M Balanos
Exp Physiol, 98: 758–767. doi:10.1113/expphysiol.2012.068528

ATP-mediated vasodilatation occurs via activation of inwardly rectifying potassium channels in humans
Anne R. Crecelius, Brett S. Kirby, Gary J. Luckasen, Dennis G. Larson, and Frank A. Dinenno
J Physiol, 590: 5349–5359. doi:10.1113/jphysiol.2012.234245

Ageing and cardiorespiratory response to hypoxia
François J. Lhuissier, Florence Canouï-Poitrine, and Jean-Paul Richalet
J Physiol,  590: 5461–5474. doi:10.1113/jphysiol.2012.238527

Myenteric neurons of the mouse small intestine undergo significant electrophysiological and morphological changes during postnatal development
Jaime Pei Pei Foong, Trung V. Nguyen, John B. Furness, Joel C. Bornstein, and Heather M. Young
J Physiol, 590: 2375–2390. doi:10.1113/jphysiol.2011.225938

Activation of the basolateral membrane Cl− conductance essential for electrogenic K secretion suppresses electrogenic Cl− secretion
Quanhua He, Susan T. Halm, Jin Zhang, and Dan R. Halm
Exp Physiol, 96: 305–316. doi:10.1113/expphysiol.2010.055038

VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells
Lisa C. Jones, Lama Moussa, M. Leslie Fulcher, Yunxiang Zhu, Elizabeth J. Hudson, Wanda K. O'Neal, Scott H. Randell, Eduardo R. Lazarowski, Richard C. Boucher, and Silvia M. Kreda
J Physiol, 590: 545–562. doi:10.1113/jphysiol.2011.222091

P2Y2 receptor activation opens pannexin-1 channels in rat carotid body type II cells: potential role in amplifying the neurotransmitter ATP
Min Zhang, Nikol A. Piskuric, Cathy Vollmer, and Colin A. Nurse
J Physiol, 590: 4335–4350. doi:10.1113/jphysiol.2012.236265

Firing patterns of spontaneously active motor units in spinal cord-injured subjects
Inge Zijdewind and Christine K. Thomas
J Physiol, 590: 1683–1697. doi:10.1113/jphysiol.2011.220103

Store-operated channels regulate intracellular calcium in mammalian rods
Tünde Molnar, Peter Barabas, Lutz Birnbaumer, Claudio Punzo, Vladimir Kefalov, and David Križaj
J Physiol, 590: 3465–3481. doi:10.1113/jphysiol.2012.234641

'Autonomic conflict': a different way to die during cold water immersion?
Michael J. Shattock and Michael J. Tipton
J Physiol, 590: 3219–3230. doi:10.1113/jphysiol.2012.229864

Comparison of blood pressure and sympathetic activity of rabbits in their home cage and the laboratory environment
Kyungjoon Lim, Sandra L Burke, James A. Armitage, and Geoffrey A Head
Exp Physiol, 97: 1263–1271. doi:10.1113/expphysiol.2012.064972

Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat
Ana P Abdala, Fiona D McBryde, Nephtali Marina, Emma B Hendy, Zoar Engelman, Marat Fudim, Paul A Sobotka, Alexander Gourine, and Julian Paton
J Physiol, 590: 4269–4277. doi:10.1113/jphysiol.2012.237800

Investigation of the neuroanatomical substrates of reward seeking following protracted abstinence in mice
Heather B. Madsen, Robyn M. Brown, Jennifer L. Short, and Andrew J. Lawrence
J Physiol, 590: 2427–2442. doi:10.1113/jphysiol.2011.225219

Augmented cholesterol absorption and sarcolemmal sterol enrichment slow small intestinal transit in mice, contributing to cholesterol cholelithogenesis
Meimin Xie, Vijay R. Kotecha, Jon David P. Andrade, James G. Fox, and Martin C. Carey
J Physiol, 590: 1811–1824. doi:10.1113/jphysiol.2011.224717

S-Glutathionylation of troponin I (fast) increases contractile apparatus Ca2 sensitivity in fast-twitch muscle fibres of rats and humans
J. P. Mollica, T. L. Dutka, T. L. Merry, C. R. Lamboley, G. K. McConell, M. J. McKenna, R. M. Murphy, and G. D. Lamb
J Physiol, 590: 1443–1463. doi:10.1113/jphysiol.2011.224535

Augmented single-unit muscle sympathetic nerve activity in heart failure with chronic atrial fibrillation
Tatsunori Ikeda, Hisayoshi Murai, Shuichi Kaneko, Soichiro Usui, Daisuke Kobayashi, Manabu Nakano, Keiko Ikeda, Shin-ichiro Takashima, Takeshi Kato, Masaki Okajima, Hiroshi Furusho, and Masayuki Takamura
J Physiol, 590: 509–518. doi:10.1113/jphysiol.2011.223842

Shaping a new Ca2 conductance to suppress early afterdepolarizations in cardiac myocytes
Roshni V. Madhvani, Yuanfang Xie, Antonios Pantazis, Alan Garfinkel, Zhilin Qu, James N. Weiss, and Riccardo Olcese
J Physiol,  589: 6081–6092. doi:10.1113/jphysiol.2011.219600

Muscle afferent activation causes ventilatory and cardiovascular responses during concurrent hypercapnia in humans
Richard M. Bruce and Michael J. White
Exp Physiol, 97: 208–218. doi:10.1113/expphysiol.2011.061606

The regulation of K- and L-cell activity by GLUT2 and CasR in rat small intestine
Oliver J Mace, Marcus Schindler, and Sonal Patel
J Physiol, 590: 2917–2936. doi:10.1113/jphysiol.2011.223800

Regulation of ventral surface CO2/H -sensitive neurons by purinergic signalling
Ian C Wenker, Cleyton R Sobrinho, Ana C Takakura, Thiago S Moreira, and Daniel K Mulkey
J Physiol, 590: 2137–2150. doi:10.1113/jphysiol.2012.229666

Ca2+ transients in myenteric glial cells during the colonic migrating motor complex in the isolated murine large intestine
Matthew J. Broadhead, Peter O. Bayguinov, Takanobu Okamoto, Dante J. Heredia, and Terence K. Smith
J Physiol, 590: 335–350. doi:10.1113/jphysiol.2011.219519

Phosphodiesterase 4 inhibition attenuates plasma volume loss and transvascular exchange in volume-expanded mice
Yueh-Chen Lin, Roger H. Adamson, Joyce F. Clark, Rolf K. Reed, and Fitz-Roy E. Curry
J Physiol, 590: 309–322. doi:10.1113/jphysiol.2011.213447

Postsynaptic mechanisms of CO2 responses in parafacial respiratory neurons of newborn rats
Hiroshi Onimaru, Keiko Ikeda, and Kiyoshi Kawakami
J Physiol, 590: 1615–1624. doi:10.1113/jphysiol.2011.222687 

Systemic cholecystokinin amplifies vago-vagal reflex responses recorded in vagal motor neurones
Edouard Viard, Richard C. Rogers, and Gerlinda E. Hermann
J Physiol, 590: 631–646. doi:10.1113/jphysiol.2011.224477

Effect of muscle metaboreflex activation on spontaneous cardiac baroreflex sensitivity during exercise in humans
Doreen Hartwich, William E. Dear, Jessica L. Waterfall, and James P. Fisher
J Physiol, 589: 6157–6171. doi:10.1113/jphysiol.2011.219964

(–)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle
Leonardo Nogueira, Israel Ramirez-Sanchez, Guy A. Perkins, Anne Murphy, Pam R. Taub, Guillermo Ceballos, Francisco J. Villarreal, Michael C. Hogan, and Moh H. Malek
J Physiol, 589: 4615–4631. doi:10.1113/jphysiol.2011.209924

Losartan abolishes oxidative stress induced by intermittent hypoxia in humans 
Vincent Pialoux, Glen E. Foster, Sofia B. Ahmed, Andrew E. Beaudin, Patrick J. Hanly, and Marc J. Poulin
J Physiol, 589: 5529–5537. doi:10.1113/jphysiol.2011.218156


Involvement of metabotropic glutamate receptor 5 in pudendal inhibition of nociceptive bladder activity in cats
Jeffrey A. Larson, P. Dafe Ogagan, Guoqing Chen, Bing Shen, Jicheng Wang, James R. Roppolo, William C. de Groat, and Changfeng Tai
J Physiol, 589: 5833–5843. doi:10.1113/jphysiol.2011.215657

Processing of central and reflex vagal drives by rat cardiac ganglion neurones: an intracellular analysis
Robin M. McAllen, Lauren M. Salo, Julian F. R. Paton, and Anthony E. Pickering
J Physiol, 589: 5801–5818. doi:10.1113/jphysiol.2011.214320

Single-unit muscle sympathetic nervous activity and its relation to cardiac noradrenaline spillover
Elisabeth A. Lambert, Markus P. Schlaich, Tye Dawood, Carolina Sari, Reena Chopra, David A. Barton, David M. Kaye, Mikael Elam, Murray D. Esler, and Gavin W. Lambert
J Physiol, 589: 2597–2605. doi:10.1113/jphysiol.2011.205351

Frontal cerebral cortex blood flow, oxygen delivery and oxygenation during normoxic and hypoxic exercise in athletes
Ioannis Vogiatzis, Zafeiris Louvaris, Helmut Habazettl, Dimitris Athanasopoulos, Vasilis Andrianopoulos, Evgenia Cherouveim, Harrieth Wagner, Charis Roussos, Peter D. Wagner, and Spyros Zakynthinos
J Physiol, 589: 4027–4039. doi:10.1113/jphysiol.2011.210880

Novel events in the molecular regulation of muscle mass in critically ill patients
Despina Constantin, Justine McCullough, Ravi P. Mahajan, and Paul L. Greenhaff
J Physiol, 589: 3883–3895. doi:10.1113/jphysiol.2011.206193

Cross-reactivity of acid-sensing ion channel and Na –H exchanger antagonists with nicotinic acetylcholine receptors
Julio Santos-Torres, Marta A. Ślimak, Sebastian Auer, and Inés Ibañez-Tallon
J Physiol, 589: 5109–5123. doi:10.1113/jphysiol.2011.213272

Exercise-induced oxidative-nitrosative stress is associated with impaired dynamic cerebral autoregulation and blood-brain barrier leakage
Damian M Bailey, Kevin A Evans, Jane McEneny, Ian S Young, David A Hullin, Philip E James, Shigehiko Ogoh, Philip N Ainslie, Céline Lucchesi, Antal Rockenbauer, Marcel Culcasi, and Sylvia Pietri
Exp Physiol, 96: 1196–1207. doi:10.1113/expphysiol.2011.06017

Purinergic modulation of preBötzinger complex inspiratory rhythm in rodents: the interaction between ATP and adenosine
J. D. Zwicker, V. Rajani, L. B. Hahn, and G. D. Funk
J Physiol, 589: 4583–4600. doi:10.1113/jphysiol.2011.210930

Presynaptic Ca2 influx and vesicle exocytosis at the mouse endbulb of Held: a comparison of two auditory nerve terminals
Kun-Han Lin, Sharon Oleskevich, and Holger Taschenberger
J Physiol, 589: 4301–4320. doi:10.1113/jphysiol.2011.209189

Effects of vagal stimulation and applied acetylcholine on pacemaker potentials in the guinea-pig heart
G D Campbell, F R Edwards, G D Hirst, and J E O'Shea
J Physiol, 415 doi: 10.1113/jphysiol.1989.sp017711.

Kinetic control of oxygen consumption during contractions in self-perfused skeletal muscle
Rob C. I. Wüst, Bruno Grassi, Michael C. Hogan, Richard A. Howlett, L. Bruce Gladden, and Harry B. Rossiter
J Physiol, 589: 3995–4009. doi:10.1113/jphysiol.2010.203422

Allodynia mediated by C-tactile afferents in human hairy skin
Saad S. Nagi, Troy K. Rubin, David K. Chelvanayagam, Vaughan G. Macefield, and David A. Mahns
J Physiol,  589: 4065–4075. doi:10.1113/jphysiol.2011.211326

The cerebrovascular response to carbon dioxide in humans
A. Battisti-Charbonney, J. Fisher, and J. Duffin
J Physiol, 589: 3039–3048. doi:10.1113/jphysiol.2011.206052

Inhibition of K+ secretion in the distal nephron in nephrotic syndrome: possible role of albuminuria
Marc Fila, Gaëlle Brideau, Luciana Morla, Lydie Cheval, Georges Deschênes, and Alain Doucet
J Physiol, 589: 3611–3621. doi:10.1113/jphysiol.2011.20969

Brainstem serotonin deficiency in the neonatal period: autonomic dysregulation during mild cold stress
Kevin J. Cummings, Aihua Li, and Eugene E. Nattie
J Physiol, 589: 2055–2064. doi:10.1113/jphysiol.2010.203679

On the contribution of group III and IV muscle afferents to the circulatory response to rhythmic exercise in humans
Markus Amann, Sean Runnels, David E Morgan, Joel Trinity, Anette Fjeldstad, David W Wray, Van R Reese, and Russell S Richardson
J Physiol, 589: 3855–3866. doi:10.1113/jphysiol.2011.209353

Probing the regulation of TASK potassium channels by PI(4,5)P2 with switchable phosphoinositide phosphatases
Moritz Lindner, Michael G. Leitner, Christian R. Halaszovich, Gerald R. V. Hammond, and Dominik Oliver
J Physiol, 589: 3149–3162. doi:10.1113/jphysiol.2011.208983

GABAergic control of micturition within the periaqueductal grey matter of the male rat
E. Stone, J. H. Coote, J. Allard, and T. A. Lovick
J Physiol, 589: 2065–2078. doi:10.1113/jphysiol.2010.202614

Cortical feedback regulation of input to visual cortex: role of intrageniculate interneurons
Sigita Augustinaite, Yuchio Yanagawa, and Paul Heggelund
J Physiol, 589: 2963–2977. doi:10.1113/jphysiol.2011.205542

Hamstring contractures in children with spastic cerebral palsy result from a stiffer extracellular matrix and increased in vivo sarcomere length
Lucas R. Smith, Ki S. Lee, Samuel R. Ward, Henry G. Chambers, and Richard L. Lieber
J Physiol, 589: 2625–2639. doi:10.1113/jphysiol.2010.203364

Altered sympathetic reflexes and vascular reactivity in rats after exposure to chronic intermittent hypoxia
Ana Q. Silva and Ann M. Schreihofer
J Physiol, 589: 1463–1476. doi:10.1113/jphysiol.2010.200691